Main objective behind this work is to study and analyze the performance of copper-oxide nanofluids with water as base fluid in the flat tube bent through 90⁰ and inlet flow temperature of 40 ℃. The simulation has been carried out using Finite volume method under Reynolds number existing between 1000-5000 and volume concentrations betweenPerformance of flat tube bent at 90⁰ was compared with performance of straight flat tube under same conditions. The various thermo-physical properties i.e. density, thermal conductivity, viscosity and specific heat capacity has been determined with well-developed models of each presented during previous studies carried out in the field of nanofluids. It was observed during this study that heat performance of nanofluids under different volume concentrations between 0.1 % to 0.4 % v/v of nanoparticles is better than that of base fluids and also increased by almost 19-20 % due to presence of bend in between flat tube. The pressure drop is also increased by with use of nanofluids. The study also proves that use of nanofluids can play very important role in decreasing overall size of heat transfer systems.