Vesicle Delivery Systems of Biologically Active Compounds: From Liposomes to Cerasomes

Denieva, Zaret G.; Буданова, У. А.; Sebyakin, Yu. L.

doi:10.1134/s1990747820050049

Cited by 1 publication

(1 citation statement)

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“…The history of liposome discovery and application began in the 1960s with the work of Alec Bangham and colleagues, who experimented with phospholipids in aqueous media and discovered their ability to form membrane-like structures [ 26 ]. Currently, liposomes are widely used as biological nanocontainers for drug delivery in oncology [ 27 , 28 ], ophthalmology [ 29 ], dermatology [ 30 ], gene therapy [ 31 ], and other fields of medicine. The undeniable advantages of liposomes include their biodegradability, low immunogenicity, and ability to interact with the cell membrane, ensuring intracellular delivery of their contents [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Liposomes of Various Compositions on the Skin and Its Derivatives After II–IIIA Degree Thermal Burns

Pashkevich,

Vilyanen,

Marcinkevich

et al. 2024

Acta Naturae

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This study examines the pathological processes and conditions arising from an experimental modeling of II–IIIA degree thermal burns in laboratory animals. These conditions are characterized by skin structure defects, diminished skin functions, especially the barrier function, and damage to skin derivatives like hair follicles and sebaceous glands. We compared the effect of liposomes composed of soybean lecithin of 90% phosphatidylcholine content and liposomes composed of lecithin of 26% phosphatidylcholine content on the epidermis, dermis and its capillaries, hair follicles, and the sebaceous glands of the laboratory animals 24 h after experimental modeling of II–IIIA degree thermal skin burns. We discuss the dependency of liposome effects on the skin and its derivatives on the fatty acid composition of the lecithin used, with particular focus on phosphatidylinositol, phosphatidic acids, as well as oleic and linoleic acids.

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