Vesicles Formed in Aqueous Mixtures of Cholesterol and Imidazolium Surface Active Ionic Liquid: A Comparison with Common Cationic Surfactant by Water Dynamics

Abstract

The formation of stable unilamellar vesicles which hold great potential for biological as well as biomedical applications has been reported in the aqueous mixed solution of a surface active ionic liquid (SAIL), 1-hexadecyl-3-methylimidazolium chloride ([C16mim]Cl) and cholesterol. To make a comparison we have also shown the formation of such stable vesicles using a common cationic surfactant, benzyldimethylhexadecylammonium chloride (BHDC) which has a similar alkyl chain length but different headgroup region to that of [C16mim]Cl. It has been revealed from dynamic light scattering (DLS), transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), and other optical spectroscopic techniques that the micelles of [C16mim]Cl and BHDC in aqueous solutions transform into stable unilamellar vesicles upon increasing concentration of cholesterol. We find that, as the concentration of cholesterol increases, the solvation and rotational relaxation time of C153 in [C16mim]Cl/cholesterol solution as well as in BHDC/cholesterol solution gradually increases indicating a significant decrease in the hydration behavior around the self-assemblies upon micelle-vesicle transition. However, the extent of increase in solvation and rotational relaxation time is more prominent in the case of [C16mim]Cl/cholesterol solutions than in the BHDC/cholesterol system. This indicates that [C16mim]Cl/cholesterol vesicular membranes are comparatively less hydrated and more rigid than the BHDC/cholesterol vesicular bilayer.

Modulation of the aggregation properties of sodium deoxycholate in presence of hydrophilic imidazolium based ionic liquid: water dynamics study to probe the structural alteration of the aggregates

“…The emission spectrum of C-153 is very much broader in nature at l exc = 375 nm and as we shift the excitation wavelengths from 375 to 440 nm the broadness of the spectrum is decreased. 53 These observations are not surprising since both bile salts and cholesterol have a similar steroidal skeleton type structure. 53 These observations are not surprising since both bile salts and cholesterol have a similar steroidal skeleton type structure.…”

How Does the Surface Charge of Ionic Surfactant and Cholesterol Forming Vesicles Control Rotational and Translational Motion of Rhodamine 6G Perchlorate (R6G ClO4)?

“…27 Very recently, we have characterized cholesterol-induced vesicle formation in aqueous solution of 1-hexadecyl-3-methylimidazolium chloride ([C 16 mim]Cl) and benzyldimethylhexadecylammonium chloride (BHDC). 30 However, to the best of our knowledge, there is no such report related to micelle−vesicle transition in common anionic surfactant solution with the addition of cholesterol.…”

“…28,29 Additionally, the hydrated mixture of cationic long alkyl chaincontaining amphiphilic molecules is capable of forming unilamellar vesicles in aqueous solution. 13,27,30 Ventosa and coworkers reported the detailed mechanisms regarding the formation of vesicles in aqueous solution of cationic surfactant, cetyltrimethylammonium bromide (CTAB) with increasing cholesterol content. 27 Very recently, we have characterized cholesterol-induced vesicle formation in aqueous solution of 1-hexadecyl-3-methylimidazolium chloride ([C 16 mim]Cl) and benzyldimethylhexadecylammonium chloride (BHDC).…”

5-Methyl Salicylic Acid-Induced Thermo Responsive Reversible Transition in Surface Active Ionic Liquid Assemblies: A Spectroscopic Approach

“…[9][10][11][12] In aqueous solution, the transition from micelle to vesicle is commonly influenced by various external stimuli; therefore this has been executed by variation in the ratio of cationic and anionic surfactants, polar additives, temperature, salts etc. [13][14][15][16][17][18][19][20][21] The morphology of the aggregates sometimes depends on the nature of additives. 14,[22][23][24][25] Considering the influence of organic additive in aggregate transition, we have been motivated to study micelle-elongated micelle-vesicle transition using room temperature ionic liquids as amphiphiles.…”