Vesicular (liposomal and nanoparticulated) delivery of curcumin: a comparative study on carbon tetrachloride–mediated oxidative hepatocellular damage in rat model

Abstract

Abstract:The liver plays a vital role in biotransforming and extricating xenobiotics and is thus prone to their toxicities. Short-term administration of carbon tetrachloride (CCl 4 ) causes hepatic inflammation by enhancing cellular reactive oxygen species (ROS) level, promoting mitochondrial dysfunction, and inducing cellular apoptosis. Curcumin is well accepted for its antioxidative and anti-inflammatory properties and can be considered as an effective therapeutic agent against hepatotoxicity. However, its therapeutic efficacy is compromised due to its insolubility in water. Vesicular delivery of curcumin can address this limitation and thereby enhance its effectiveness. In this study, it was observed that both liposomal and nanoparticulated formulations of curcumin could increase its efficacy significantly against hepatotoxicity by preventing cellular oxidative stress. However, the best protection could be obtained through the polymeric nanoparticle-mediated delivery of curcumin. Mitochondria have a pivotal role in ROS homeostasis and cell survivability. Along with the maintenance of cellular ROS levels, nanoparticulated curcumin also significantly (P,0.0001) increased cellular antioxidant enzymes, averted excessive mitochondrial destruction, and prevented total liver damage in CCl 4 -treated rats. The therapy not only prevented cells from oxidative damage but also arrested the intrinsic apoptotic pathway. In addition, it also decreased the fatty changes in hepatocytes, centrizonal necrosis, and portal inflammation evident from the histopathological analysis. To conclude, curcumin-loaded polymeric nanoparticles are more effective in comparison to liposomal curcumin in preventing CCl 4 -induced oxidative stress-mediated hepatocellular damage and thereby can be considered as an effective therapeutic strategy.

Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing

“…Curcumin, a naturally occurring small-molecule compound, has anti-inflammatory and antibacterial properties among other biological activities (Guo et al., 2011 ). However, its low water solubility restricts its clinical use (Choudhury et al., 2016 ). Our previous study shows that curcumin loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly (ε-caprolactone) (Cur/PCEC) nanofibers can increase the bioavailability and stability of curcumin hence enhance wound healing (Fu et al., 2014 ).…”

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

“…However, the therapeutic application of curcumin is limited by its high hydrophobicity with poor water solubility, photosensitivity, chemical instability, and rapid metabolism rate [4–5]. Therefore, as a result, systemic bioavailability is much reduced [6]. The use of nanoparticles as drug delivery systems is currently a corner stone in the field of drug delivery in order to improve the pharmacokinetics and pharmacodynamics of many drugs that have limitations in bioavailability [7].…”