Vesicular pemphigoid in a 16-year-old boy

Childhood Bullous Pemphigoid: Report of Three Cases

“…Our three cases show similar DIF results, i.e., IgG and C3 deposits at the BMZ by DIF. Regarding salt‐spilt skin, two out of our three cases had IgG deposits at the epidermal side of the split, which meets the majority of cases so far reported (4, 18). Although some authors emphasize the importance of the IB test for the diagnosis of BP (19, 20, 22), in a recent study comparing the different laboratory techniques, the sensitivity of traditional diagnostic tests, DIF (91%) and IIF (96%), were comparable with those of the newer techniques, IB analysis (100%) and ELISA (96%) (23).…”

“…Approximately 50 cases of childhood BP have been described so far (4–20, 22, 24–30). The age range reported varies between 2 months and 16 years (7, 18), and nearly one fourth of them were younger than 1 year (3–17). Typical clinical findings in childhood include blisters on the hands and feet.…”

Atypical presentations of bullous pemphigoid: Clinical and immunopathological aspects

“…Patients present with numerous small pruritic tense vesicles often on an urticarial or erythematous base symmetrically distributed on extremities and trunk, as seen in dermatitis herpetiformis [45][46][47]. Cases are reported mostly in elderly people [45] and sometimes in children as well [48,49]. Therapies using systemic corticosteroid combined with minocycline are usually effective [45].…”

Vesicular pemphigoid with circulating autoantibodies against 230‐kDa and 180‐kDa proteins, and additional autoantibodies against 97‐kDa and 45‐kDa proteins

“…VP is an uncommon variant of BP, occurring mostly in the elderly, 8–14 with adolescent cases rarely being described 11 . Although several circulating autoantibodies against polypeptides other than BPAG1 and BPAG2, such as 280/270 kDa, 15 120 kDa, 16 97 kDa, 17 and desmoplakins, 18 have been detected in BP patients, their pathogenic roles remain largely undefined.…”