Vesicular stomatitis virus induces apoptosis at early stages in the viral cycle and does not depend on virus replication

Gadaleta, Patricia; Vacotto, Marina; Coulombié, Félix C.

doi:10.1016/s0168-1702(02)00049-7

Cited by 40 publications

(31 citation statements)

References 24 publications

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“…of 1. Infection with Sendai virus (SeV, 20 HA ml 21 ), which is known to be a potent inducer of apoptosis, served as a positive control (Gadaleta et al, 2002). The formation of CPE in infected cells, as well as known hallmarks of apoptosis, including caspase 3 cleavage and chromatin condensation, were monitored.…”

Section: Resultsmentioning

confidence: 99%

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

Wolff

Groseth

Meyer

et al. 2016

Journal of General Virology

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The Arenaviridae is a diverse and growing family of viruses that already includes more than 25 distinct species. While some of these viruses have a significant impact on public health, others appear to be non-pathogenic. At present little is known about the host cell responses to infection with different arenaviruses, particularly those found in the New World; however, apoptosis is known to play an important role in controlling infection of many viruses. Here we show that infection with Tacaribe virus (TCRV), which is widely considered the prototype for non-pathogenic arenaviruses, leads to stronger induction of apoptosis than does infection with its human-pathogenic relative Junín virus. TCRV-induced apoptosis occurred in several cell types during late stages of infection and was shown to be caspase-dependent, involving the activation of caspases 3, 7, 8 and 9. Further, UV-inactivated TCRV did not induce apoptosis, indicating that the activation of this process is dependent on active viral replication/transcription. Interestingly, when apoptosis was inhibited, growth of TCRV was not enhanced, indicating that apoptosis does not have a direct negative effect on TCRV infection in vitro. Taken together, our data identify and characterize an important virus-host cell interaction of the prototypic, non-pathogenic arenavirus TCRV, which provides important insight into the growing field of arenavirus research aimed at better understanding the diversity in responses to different arenavirus infections and their functional consequences.

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Section: Resultsmentioning

confidence: 99%

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

Wolff

Groseth

Meyer

et al. 2016

Journal of General Virology

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show abstract

“…While many of the details of direct and indirect mechanisms of VSV-induced apoptosis remain to be determined, the role of viral replication in VSV oncolysis is also controversial. It Oncolytic activity of VSV in ATL R Césaire et al has been reported that VSV-induced cell death occurs at early stages after infection, and requires viral particle internalization and uncoating, but not viral replication or de novo viral protein synthesis (Gadaleta et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia

et al. 2005

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“…The viral agent VSV also triggers apoptosis of the infected cells (Kopecky et al, 2001;Gadaleta et al, 2002;Sur et al, 2003). In order to determine if apoptosis induced by VSV infection in MEFs derived from the transgenic mice correlated with lower viral yields in these cells, MEFs from WT, p53À/À or 'super p53' mice were infected with 1 PFU/cell of VSV, and 24 h after infection, cells were processed to determine apoptosis induction.…”

mentioning

confidence: 99%

Resistance to viral infection of super p53 mice

et al. 2005

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Vesicular stomatitis virus induces apoptosis at early stages in the viral cycle and does not depend on virus replication

Cited by 40 publications

References 24 publications

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia

Resistance to viral infection of super p53 mice

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