Vesicular systems employing natural substances as promising drug candidates for MMP inhibition in glioblastoma: A nanotechnological approach

Agarwal, Srishti; Muniyandi, Priyadharshni; Maekawa, Toru; Kumar, D. Sakthi

doi:10.1016/j.ijpharm.2018.09.033

Cited by 23 publications

(10 citation statements)

References 195 publications

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“…Preclinical development and clinical validation of novel therapeutic modalities for efficient treatment of malignant brain tumors represents one of the highly significant challenges of contemporary experimental and clinical oncology [42][43][44][45]. Experimental therapeutics of tetrac and its formulations have shown promising in vitro and in vivo activities against a broad spectrum of human malignancies, including gliomas [11,14,39,40,46].…”

Section: Discussionmentioning

confidence: 99%

Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells

Glinsky¹,

Godugu²,

Sudha³

et al. 2022

Preprint

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Chemically modified forms of tetraiodothyroacetic acid (tetrac), an L-thyroxine derivative, have been shown to exert their anticancer activity at plasma membrane integrin αvβ3 of tumor cells. Via a specific hormone receptor on the integrin, tetrac-based therapeutic agents modulate expression of genes relevant to cancer cell proliferation, survival and energy metabolism. P-bi-TAT, a novel bivalent tetrac-containing synthetic compound has anticancer activity in vitro and in vivo against Glioblastoma Multiforme (GBM) and other types of human cancers. In the current study, microarray analysis was carried out on a primary culture of human GBM cells exposed to P-bi-TAT (10-6 tetrac equivalent) for 24 h. P-bi-TAT significantly affected expression of a large panel of genes implicated in cancer cell stemness, growth, survival, and angiogenesis. Recent interest elsewhere in ATP synthase as a target in GBM cells caused us to focus attention on expression of genes involved in energy metabolism. Significantly downregulated transcripts included multiple energy metabolism-related genes: electron transport chain genes ATP5A1 (ATP synthase 1), ATP51, ATP5G2, COX6B1 (cytochrome c oxidase subunit 6B1), NDUFA8 (NADH dehydrogenase [ubiquinone] FA8), NDUFV2I and other NDUF genes. The NDUF and ATP genes are also relevant to control of oxidative phosphorylation and transcription. Qualitatively similar actions of P-bi-TAT on expression of energy metabolism-linked genes were also detected in established human GBM and pancreatic cancer cell lines. In conclusion, acting at αvβ3 integrin, P-bi-TAT caused downregulation in human cancer cells of expression of a large number of genes involved in electron transport and oxidative phosphorylation. These observations suggest that cell surface thyroid hormone receptors on αvβ3 regulate expression of genes relevant to tumor cell stemness and energy metabolism.

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Section: Discussionmentioning

confidence: 99%

Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells

Glinsky¹,

Godugu²,

Sudha³

et al. 2022

Preprint

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“…As a result, studies have been conducted to prove the need for advanced pharmaceutical preparations that will help treat burns faster and reduce cost. Further explanations of the advantages and limitations of lipid-based vesicular drug delivery systems (DDSs) are displayed in Table 4 [10]. Thus, based on the previously reported research work, it seems that many drug formulation problems can be addressed with vesiculosomes to improve drug therapeutic efficacy and patient compliance.…”

Section: Vesicular Drug Delivery Systemsmentioning

confidence: 99%

“…Liposomes are spherical vesicular particles with an aqueous center encased by one or more concentric phospholipid bilayers (Figure 1). Since the 1970s, liposomes have been explored as potential DDSs because of their numerous advantages, such as their ability to incorporate hydrophilic and hydrophobic active pharmaceutical agents (APIs), reduce the risk of severe adverse effects of toxic drugs such as chemotherapeutics [10], target drugs to a specific site of action, improve drug bioavailability, control the release pattern of medication over a long duration, and minimize the frequency of the dose, thus improving patient compliance [11]. Liposomes have been applied in various pharmacotherapeutic areas to improve therapeutic drug performance from different routes of administration including oral, topical, parenteral, ocular, and nasal [12][13][14][15].…”

Section: Liposomesmentioning

confidence: 99%

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

et al. 2022

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Burn injuries can have a lasting effect on people’s quality of life, as they negatively impact their physical and mental health. Then, they are likely to suffer psychological problems as a result. A serious problem is that deep burns are more challenging to treat due to their slow healing rate and susceptibility to microbial infection. Conventional topical medications used for burn treatment are sometimes ineffective because they cannot optimize their ability of transcutaneous absorption at the targeted site and accelerate healing. However, nanotechnology offers excellent prospects for developing current medical wound therapies and is capable of addressing issues such as low drug stability, water solubility, permeability, and bioavailability. The current review focuses on lipid-based vesicles (vesiculosomes) as an example of advanced delivery systems, showing their potential clinical applications in burn wound management. Vesiculosomes may help overcome impediments including the low bioavailability of active agents, offering the controlled release of drugs, increased drug stability, fewer side effects, and reduced dosing frequency, which will ultimately improve therapeutic efficacy and patient compliance. We discuss the application of various types of vesiculosomes such as liposomes, niosomes, ethosomes, cubosomes, transfersomes, and phytosomes in burn healing therapy, as these demonstrate superior skin penetration compared to conventional burn topical treatment. We also highlight their noteworthy uses in the formulation of natural products and discuss the current status as well as future perspectives of these carriers in burn management. Furthermore, the burn treatment options currently available in the market are also summarized.

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“…Fifth, active targeting can be achieved by attaching substances to nanoparticles that specifically target a part of GBM tumor cells [6], such as an antigen (i.e., A2B5), differentiation clusters (i.e., CD15, CD33, CD44, or CD133), receptors of cytokines (i.e., interleukin13 receptor), and several proteins (i.e., Integrin-a6, α 5 β 3 , ανβ 3 or L1CAM), which are expressed in GBM cells and can promote tumorigenesis. Examples of such substances include CTX, Pep-1, CBP4 and RGD, targeting CIC-13 chloride channel/matrix metalloproteinase (MMP-2), Interleukin13 receptor, CD33 and α 5 β 3 /ανβ 3 , respectively [48,71,77].…”

Section: Nano-drugs Improve Gbm Drug Deliverymentioning

confidence: 99%

Nano-Therapies for Glioblastoma Treatment

Alphandéry

2020

Cancers

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Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation by enabling: (i) an increase of anti-glioblastoma multiforme (GBM) activity of chemo/gene therapeutic drugs, notably by an improved diffusion of these drugs through the blood brain barrier (BBB), (ii) the sensibilization of radio-resistant GBM tumor cells to radiotherapy, (iii) the removal by surgery of infiltrating GBM tumor cells, (iv) the restoration of an apoptotic mechanism of GBM cellular death, (v) the destruction of angiogenic blood vessels, (vi) the stimulation of anti-tumor immune cells, e.g., T cells, NK cells, and the neutralization of pro-tumoral immune cells, e.g., Treg cells, (vii) the local production of heat or radical oxygen species (ROS), and (viii) the controlled release/activation of anti-GBM drugs following the application of a stimulus. This review covers these different aspects.

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Vesicular systems employing natural substances as promising drug candidates for MMP inhibition in glioblastoma: A nanotechnological approach

Cited by 23 publications

References 195 publications

Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells

Effects of Anticancer Agent P-bi-TAT on Gene Expression Link the Integrin Thyroid Hormone Receptor to Expression of Stemness and Energy Metabolism Genes in Cancer Cells

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

Nano-Therapies for Glioblastoma Treatment

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