Vesicular systems for dermal and transdermal drug delivery

Richard, Claire; Cassel, Stéphanie; Blanzat, Muriel

doi:10.1039/d0ra09561c

Cited by 38 publications

(33 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1) (Sarhan et al 2020;Wu et al 2019). Edge Activator has a 25% usage limit on Transfersomes (Richard, Cassel, and Blanzat 2020). Thus, vesicle size is reduced as a result of increased solubility.…”

Section: Transfersomementioning

confidence: 99%

Transfersome as Topical Drug Delivery: Formulation and Characterization

Darajat¹,

Chaerunisaa²,

Abdassah³

2023

JFG

View full text Add to dashboard Cite

A transdermal delivery system is a non-invasive delivery system that provide a controlled therapeutic effect. However, this system has a barrier that is the outermost layer of the skin, so that only part of the drug can be administered via the transdermal route. The use of the vesicular system as a carrier for drugs or active substances is a solution for transdermal delivery systems to be able to pass through the skin barrier. One of the vesicular systems that can overcome this problem is transfersome. Displacement is elastic and can change shape by squeezing itself to pass through smaller-than-sized pores. In addition, transfersomes can encapsulate drugs or active substances that are amphiphilic, and have permeation ability than conventional liposomes. This review article aims to explain the definition and general description of transfersomes, their mechanism of action, methods of preparation and characterization, and their recent application in drug delivery using the vesicular transfersome system.

show abstract

Section: Transfersomementioning

confidence: 99%

Transfersome as Topical Drug Delivery: Formulation and Characterization

Darajat¹,

Chaerunisaa²,

Abdassah³

2023

JFG

View full text Add to dashboard Cite

show abstract

“…Thus, some prospective strategies, including both chemical and physical methods, have been investigated in order to overcome the SC barrier [8,9,14,24,27]. The methods utilized to modify the barrier properties of the SC can be classified as chemical and physical methods, as summarized in Figure 3 [14,28]. Prausnitz and Langer described three generations of TDD systems in a paper published in 2008 [8].…”

Section: Techniques For Enhancement Of Skin Permeabilisationmentioning

confidence: 99%

“…The characteristics of vesicles, rather than the physicochemical properties of drug molecules, control the clearance and tissue distribution profile of a drug when delivered by such a delivery system [81]. Based on the physicochemical characteristics of the drug, it can be encapsulated in the internal cavity or be included in the bilayer [28]. Hence, vesicles can load hydrophilic, lipophilic, and amphiphilic drugs to achieve transdermal delivery [10].…”

Section: Surfactantsmentioning

confidence: 99%

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

et al. 2022

View full text Add to dashboard Cite

The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms but is as convenient and easy to use for the patient as oral solid dosage forms. In recent years, there has been increased interest in transdermal drug delivery (TDD) as a non-invasive delivery approach that is generally regarded as being easy to administer to more vulnerable age groups, such as paediatric and geriatric patients, while avoiding certain bioavailability concerns that arise from oral drug delivery due to poor absorbability and metabolism concerns. However, despite its many merits, TDD remains restricted to a select few drugs. The physiology of the skin poses a barrier against the feasible delivery of many drugs, limiting its applicability to only those drugs that possess physicochemical properties allowing them to be successfully delivered transdermally. Several techniques have been developed to enhance the transdermal permeability of drugs. Both chemical (e.g., thermal and mechanical) and passive (vesicle, nanoparticle, nanoemulsion, solid dispersion, and nanocrystal) techniques have been investigated to enhance the permeability of drug substances across the skin. Furthermore, hybrid approaches combining chemical penetration enhancement technologies with physical technologies are being intensively researched to improve the skin permeation of drug substances. This review aims to summarize recent trends in TDD approaches and discuss the merits and drawbacks of the various chemical, physical, and hybrid approaches currently being investigated for improving drug permeability across the skin.

show abstract

“…Understanding the physicochemical properties of transdermal DDSs, such as particle size, fluidity, rigidity, and carrier morphology, is important for determining the possibility of skin penetration. It has been reported that rigid liposomes can prolong transdermal delivery as they deposit the drugs on the skin surface, whereas fluid vesicles can be considered for transdermal diffusion . Understanding these basic properties and behavior is crucial for optimizing the design of a carrier for a particular purpose.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that rigid liposomes can prolong transdermal delivery as they deposit the drugs on the skin surface, whereas fluid vesicles can be considered for transdermal diffusion. 25 Understanding these basic properties and behavior is crucial for optimizing the design of a carrier for a particular purpose.…”

Section: ■ Introductionmentioning

confidence: 99%

Dependence of the Core–Shell Structure on the Lipid Composition of Nanostructured Lipid Carriers: Implications for Drug Carrier Design

Izza

Watanabe

Okamoto

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Nanostructured lipid carriers (NLCs) are a new generation of lipid vectors for drug delivery systems (DDSs), which are composed of solid and liquid lipids dispersed throughout the inner lipid matrix. This study provides molecular and physicochemical characterizations of the NLC core region. According to the fluorescence anisotropy analysis, NLCs might have a more rigid shell (high anisotropy) and a less rigid core (low anisotropy). Based on cryo-transmission electron microscopy (cryo-TEM) observations, most NLC particles had a spherical shape with a crystal-like lamellar structure that might have originated from the crystallized lipids. The NLC particles with a lower concentration of solid lipids exhibited a faceted structure formed by the crystal lattice in the outer region. This result was verified through differential scanning calorimetry (DSC), which confirmed a polymorphism of the solid lipid in NLCs. The crystal structure was confirmed by X-ray diffraction (XRD) peak intensities, which were influenced by the lipid composition. Furthermore, a linear correlation was observed between the solid lipid-to-total lipid ratio and the anisotropy gap (r gap ), transition energy (ΔH), and crystallinity percentage. These parameters can be used to predict the existence of the shell, rigid state fraction, and crystals in the NLC structure. Lipid rigidity and structural heterogeneity are essential for dispersive stability and drug-loading properties. Therefore, by adjusting the lipid composition, an optimized design of NLCs with high efficacy can be achieved for DDSs.

show abstract

Vesicular systems for dermal and transdermal drug delivery

Abstract: Dermal/transdermal drug delivery continues to grow in importance as a means of enhancing treatment activity while reducing toxicity by avoiding the systemic absorption of the drug.

Cited by 38 publications

References 100 publications

Transfersome as Topical Drug Delivery: Formulation and Characterization

Transfersome as Topical Drug Delivery: Formulation and Characterization

Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems

Dependence of the Core–Shell Structure on the Lipid Composition of Nanostructured Lipid Carriers: Implications for Drug Carrier Design

Contact Info

Product

Resources

About