Vesiculobullous Syphilis: A Case Involving an Unusual Cutaneous Manifestation of Secondary Syphilis

“…However, the rash of secondary syphilis can take on other forms such as follicular, pustular, nodular[ 33 ] or even wart-like in genital areas. It can mimic a variety of dermatological conditions such as psoriasis, eczema, tinea versicolor, lichen planus, erythema multiforme and alopecia areata;[ 34 35 ] hence, earning the eponymous nickname of the “great mimicker”. From secondary syphilis, patient can proceed either to latent stage having no symptoms but positive syphilitic serology, or, to tertiary syphilis which can affect the central nervous system (neurosyphilis), the cardiovascular system (cardiosyphilis), the skeletal system and the visceral organs.…”

Section: Syphilismentioning

confidence: 99%

Approach to Patient with a Generalized Rash

Leung

Soeyonggo

2013

J Family Med Prim Care

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Background:Generalized rash is amongst the most common conditions presented to practicing General Practitioners and common differentials include contact dermatitis, atopic eczema, sun-induced damage, drug eruption and general manifestations of systemic diseases or infections.Materials and Methods:We illustrate with differential diagnoses our clinical case of a generalized rash in a 55-year-old man with pathognomonic signs of a diagnosis, which has received increasing global concern.Conclusion:Despite the array of available laboratory tests, a detailed history and physical examination is still of paramount importance to arrive at the most likely diagnosis for any patient with a generalized skin rash.

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“…Syphilis has been reported to assume uncommon clinical appearances, especially in patients infected with HIV type 1 [5]. A rare form of the disease is malignant syphilis, which is a form of destructive syphilid, with ulcerative lesions and severe toxemia that may have a lethal outcome [6, 7]. The ulcers, commonly seen over the face and the extremities, are covered with thick crusts, which heal slowly [6, 7].…”

Section: Introductionmentioning

confidence: 99%

“…A rare form of the disease is malignant syphilis, which is a form of destructive syphilid, with ulcerative lesions and severe toxemia that may have a lethal outcome [6, 7]. The ulcers, commonly seen over the face and the extremities, are covered with thick crusts, which heal slowly [6, 7]. The mucous membranes of the mouth and the nose may be involved, and prodroma such as fever, myalgia, and headache are common [1, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

Atypical secondary syphilis presentation in a patient with human immunodeficiency virus infection: a case report

2019

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IntroductionUntreated syphilis may lead to severe complications. This infection has recently re-emerged in developed countries with a high number of cases coinfected with human immunodeficiency virus. In these patients, the skin lesions of secondary syphilis can be very atypical.Case presentationWe report the case of a 38-year-old Bulgarian homosexual man who was coinfected with human immunodeficiency virus and syphilis. His skin contained multiple extensive necrotic lesions with abundant purulent secretion that covered his face, lips, scalp, and torso. Initial clinical diagnoses included varicella pustulosa and staphylococcal dermatitis. Human immunodeficiency virus infection in our patient had been established 2 years earlier in prophylactic studies, but had not been treated. Due to lack of penicillin, he was successfully treated with ceftriaxone, and the skin lesions underwent complete reversal. He also began antiretroviral therapy, which resulted in a significant effect on his immune status. Three months after the onset of antiretroviral therapy, he also achieved optimal viral suppression.ConclusionThis case emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of any inflammatory cutaneous disorder in individuals infected with human immunodeficiency virus.

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Vesiculobullous Syphilis: A Case Involving an Unusual Cutaneous Manifestation of Secondary Syphilis

Cited by 16 publications

References 11 publications

Infectious Diseases and Infestations of the Vulva

Infectious Diseases and Infestations of the Vulva

Approach to Patient with a Generalized Rash

Atypical secondary syphilis presentation in a patient with human immunodeficiency virus infection: a case report

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