Vesiduction: the fourth way of <scp>HGT</scp>

Soler, Nicolás; Forterre, Patrick

doi:10.1111/1462-2920.15056

Cited by 75 publications

(59 citation statements)

References 31 publications

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“…MVs are released from all living cells, are biologically active and contain different components, such as genetic material, including chromosomal and plasmid DNA, as well as different types of RNA. These vesicles can mediate the transfer of ARGs between bacteria and can persist over time in natural environments [134,135]. Environmental and external stimuli induce the release of MVs; for instance, the exposure to subinhibitory antibiotics of different classes may induce MV release and HGT mediated by MVs [134].…”

Section: Args Spread By Hgt Mechanismsmentioning

confidence: 99%

“…Environmental and external stimuli induce the release of MVs; for instance, the exposure to subinhibitory antibiotics of different classes may induce MV release and HGT mediated by MVs [134]. Although there are no studies focused on the presence of MVs in manure and their potential involvement in HGT events, manure and manured soils can be a privileged platform for HGT mediated by MVs due to the presence of antimicrobials in manure and the stress response triggered by the land application of manure in soil resident bacterial communities [135].…”

Section: Args Spread By Hgt Mechanismsmentioning

confidence: 99%

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

140

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The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts of manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria are frequently detected in manure and manure-amended soils. This review explores the role of manure in the persistence and dissemination of ARGs in the environment, analyzes the procedures used to decrease antimicrobial resistance in manure and the potential impact of manure application in public health. We highlight that manure shows unique features as a hotspot for antimicrobial gene dissemination by horizontal transfer events: richness in nutrients, a high abundance and diversity of bacteria populations and antibiotic residues that may exert a selective pressure on bacteria and trigger gene mobilization; reduction methodologies are able to reduce the concentrations of some, but not all, antimicrobials and microorganisms. Conjugation events are often seen in the manure environment, even after composting. Antibiotic resistance is considered a growing threat to human, animal and environmental health. Therefore, it is crucial to reduce the amount of antimicrobials and the load of antimicrobial resistant bacteria that end up in soil.

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Section: Args Spread By Hgt Mechanismsmentioning

confidence: 99%

Section: Args Spread By Hgt Mechanismsmentioning

confidence: 99%

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

140

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“…Moreover, the model offers no constraint for ancient viruses to propagate via virion synthesis or other means. The ancient cells simply produced vesicles that transported genetic cargo within the emergent cellular community (facilitating 'vesiduction' [42]). The vesicle-mediated transport is routinely observed in multicellular organisms and, interestingly, shows remarkable resemblances to virus exit pathways [43].…”

Section: Hybrid Models Of Virus Origins and Evolutionmentioning

confidence: 99%

The origin and evolution of viruses inferred from fold family structure

2020

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The canonical frameworks of viral evolution describe viruses as cellular predecessors, reduced forms of cells, or entities that escaped cellular control. The discovery of giant viruses has changed these standard paradigms. Their genetic, proteomic and structural complexities resemble those of cells, prompting a redefinition and reclassification of viruses. In a previous genome-wide analysis of the evolution of structural domains in proteomes, with domains defined at the fold superfamily level, we found the origins of viruses intertwined with those of ancient cells. Here, we extend these data-driven analyses to the study of fold families confirming the co-evolution of viruses and ancient cells and the genetic ability of viruses to foster molecular innovation. The results support our suggestion that viruses arose by genomic reduction from ancient cells and validate a co-evolutionary 'symbiogenic' model of viral origins.

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“…Since the virion is encoded by the wasp genome, polydnavirus-associated wasps may better resemble virion-encoding organisms under the virion-centric definition [ 31 ]. Similarly, virus-infected cells can excrete vesicles containing the virus nucleic acid, [ 32 ] and healthy cells routinely utilize extracellular vesicles for genetic communication [ 33 ]. These examples generalize the concept and morphology of a ‘virion’.…”

Section: Avoid the Presence/absence Criteria To Define Virusesmentioning

confidence: 99%

Investigating the Concept and Origin of Viruses

Nasir¹,

Romero-Severson²,

Claverie³

2020

Trends in Microbiology

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The ongoing COVID-19 pandemic has piqued public interest in the properties, evolution, and emergence of viruses. Here, we discuss how these basic questions have surprisingly remained disputed despite being increasingly within the reach of scientific analysis. We review recent data-driven efforts that shed light into the origin and evolution of viruses and explain factors that resist the widespread acceptance of new views and insights. We propose a new definition of viruses that is not restricted to the presence or absence of any genetic or physical feature, detail a scenario for how viruses likely originated from ancient cells, and explain technical and conceptual biases that limit our understanding of virus evolution. We note that the philosophical aspects of virus evolution also impact the way we might prepare for future outbreaks.

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Vesiduction: the fourth way of HGT

Cited by 75 publications

References 31 publications

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

The origin and evolution of viruses inferred from fold family structure

Investigating the Concept and Origin of Viruses

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