Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography

Parodi, Maurizio Battaglia; Cicinelli, Maria Vittoria; Rabiolo, Alessandro; Pierro, Luisa; Gagliardi, Marco; Bolognesi, Gianluigi; Bandello, Francesco

doi:10.1136/bjophthalmol-2016-308925

Cited by 108 publications

(121 citation statements)

References 25 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Furthermore, several studies demonstrated that choroidal thickness is significantly reduced in patients with RP. 34,35 In contrast to our results, Battaglia Parodi et al 16 recently showed no difference in CCP vessel density between RP patients and healthy subjects, which were tested by means of OCTA. Nevertheless, this is probably secondary to the different OCTA types used (Optovue in our study and Topcon in the Battaglia Parodi et al study), or to the different method of analysis (AngioVue software versus ImageJ software), or to different disease stages and genetic features of the groups enrolled (considering there is a poor genetic characterization in both studies).…”

Section: Discussioncontrasting

confidence: 55%

See 1 more Smart Citation

Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function

Toto

Borrelli

Mastropasqua

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To investigate correlations among macular ganglion cell complex (GCC) layer thickness, macular capillary density, and macular function in patients affected by retinitis pigmentosa (RP). METHODS.Fourteen patients (28 eyes) with previous diagnosis of RP were enrolled. The diagnosis of these conditions was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography (OCTA) and multifocal electroretinogram (mfERG). Main outcome measures were macular GCC layer thickness; superficial capillary plexus (SCP) vessel density; deep capillary plexus (DCP) vessel density; choriocapillaris plexus (CCP) vessel density; and amplitudes of mfERG N1 and P1 waves.RESULTS. Average GCC thickness was significantly thinner in RP patients (76.0 6 25.1 and 109.2 6 17.5 lm, P ¼ 0.028). Superficial capillary plexus density was 42.2 6 3.4% in the RP group and 51.4 6 2.3% in the control group (P < 0.001). Deep capillary plexus density was reduced in RP patients (42.7 6 6.2%) after the comparison with healthy subjects (56.6 6 2.2%, P < 0.001). Choriocapillaris plexus density was significantly less in RP patients than in the control group (65.3 6 2.7% and 67.2 6 1.4%, P ¼ 0.024). Superficial capillary plexus and DCP density were significantly correlated with both mfERG values and GCC thickness.CONCLUSIONS. We showed that both choroid and retinal vessels were modified in RP patients after comparison with healthy subjects. Moreover, we demonstrated that the SCP and DCP vessel densities are correlated with the macular function, as well as with the GCC thickness.

show abstract

Section: Discussioncontrasting

confidence: 55%

“…15 Battaglia Parodi et al 16 recently showed vascular alterations in RP by means of OCTA. However, they did not evaluate a possible correlation between vascular perfusion and retinal function.…”

mentioning

confidence: 99%

Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function

Toto

Borrelli

Mastropasqua

et al. 2016

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…For retinal vascular changes, studies suggest that a reduced retinal blood flow could be a response to a decreased metabolism after ganglion cell death and a loss of photoreceptors due to reactive vessel constriction [21-23]. This hypothesis has been supported by the finding of an increase in endothelin-1, a powerful endogenous vasoconstrictor factor in the eyes of retinitis pigmentosa patients [22, 24, 25]. In our study, the postvitelliform group of BVMD revealed a reduction in superficial vessel density compared to the vitelliform group, although the difference did not reach a significant level, possibly due to the limited sample size.…”

Section: Discussionsupporting

confidence: 49%

Findings of Optical Coherence Tomography Angiography in Best Vitelliform Macular Dystrophy

Wang

You

et al. 2018

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: To evaluate the vascular anatomy of eyes with Best vitelliform macular dystrophy (BVMD) using optical coherence tomography angiography (OCTA). Methods: This retrospective case-control study enrolled 11 consecutive BVMD patients and 13 age-matched healthy participants. Both eyes of each participant were imaged using a macular OCTA scan (3 × 3 mm) by 70-kHz 840-nm spectral-domain OCT. The flow signal was calculated using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. Results: Qualitative analysis showed uneven hypo- and hyperintense signal changes at the choriocapillary level in OCTA images of BVMD patients. Quantitative analysis showed significant reductions in the flow density of the superficial vascular layer (whole: 49.2% vs. 53.9%, p < 0.001) and the choriocapillary flow area (5.1 vs. 5.5 mm², p = 0.02) in BVMD patients compared to controls. The choriocapillary flow area in the postvitelliform group was reduced compared to that of the vitelliform group. There was a statistically significant association between choriocapillary flow area and superficial vascular flow density (p = 0.045), choriocapillary flow area and foveal avascular zone area (p = 0.03). Conclusions: Vascular changes in BVMD were apparent in the choriocapillary layer. The changes became more striking in late stages of the disease. OCTA provides useful quantitative measurements for staging and monitoring the progression of BVMD.

show abstract

“…The utility of this technique as an alternative to conventional fluorescein and indocyanine green angiography has been explored for numerous retinal and optic nerve diseases in the past few years with encouraging results 5–14. In addition to qualitative features (eg, subjective assessment of foveal ischaemia), several studies have now reported the use of quantitative measures (eg, retinal capillary plexus density measurements) to evaluate severity and prognosis of conditions such as diabetic retinopathy,15 age-related macular degeneration,16 Stargardt disease17 and retinitis pigmentosa 18…”

Section: Introductionmentioning

confidence: 99%

Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Fenner

Tan

et al. 2017

Br J Ophthalmol

View full text Add to dashboard Cite

show abstract

Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography

Cited by 108 publications

References 25 publications

Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function

Macular Features in Retinitis Pigmentosa: Correlations Among Ganglion Cell Complex Thickness, Capillary Density, and Macular Function

Findings of Optical Coherence Tomography Angiography in Best Vitelliform Macular Dystrophy

Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Contact Info

Product

Resources

About