Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo

Langham, Michael C; Li, Cheng; Englund, Erin K; Chirico, Erica N.; Mohler, Emile R.; Floyd, Thomas F.; Wehrli, Félix W.

doi:10.1186/1532-429x-15-100

Cited by 9 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The software has been used in more than 50 peer‐reviewed journal articles in diverse areas of NMR research. The applications include dynamic measurement of blood oxygenation and blood velocity , measurement of pulse‐wave velocity , simultaneous T2* and perfusion quantification in the leg , vessel wall imaging , high‐resolution imaging of trabecular bone , sodium imaging at the knee , MR elastography , spectrally selective 3D fast spin echo , dynamic imaging of phosphocreatine recovery kinetics , and solid‐state 1 H and 31 P cortical bone imaging . Despite the commonalities between many of the sequences for these applications, each of the above techniques required individual customization.…”

Section: Resultsmentioning

confidence: 99%

Pulse sequence programming in a dynamic visual environment: SequenceTree

Magland

Langham

et al. 2015

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Purpose To describe SequenceTree (ST), an open source. integrated software environment for implementing MRI pulse sequences, and ideally exported them to actual MRI scanners. The software is a user-friendly alternative to vendor-supplied pulse sequence design and editing tools and is suited for non-programmers and programmers alike. Methods The integrated user interface was programmed using the Qt4/C++ toolkit. As parameters and code are modified, the pulse sequence diagram is automatically updated within the user interface. Several aspects of pulse programming are handled automatically allowing users to focus on higher-level aspects of sequence design. Sequences can be simulated using a built-in Bloch equation solver and then exported for use on a Siemens MRI scanner. Ideally other types of scanners will be supported in the future. Results The software has been used for eight years in the authors’ laboratory and elsewhere and has been utilized in more than fifty peer-reviewed publications in areas such as cardiovascular imaging, solid state and non-proton NMR, MR elastography, and high resolution structural imaging. Conclusion ST is an innovative, open source, visual pulse sequence environment for MRI combining simplicity with flexibility and is ideal for both advanced users and those with limited programming experience.

show abstract

Section: Resultsmentioning

confidence: 99%

Pulse sequence programming in a dynamic visual environment: SequenceTree

Magland

Langham

et al. 2015

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…Magnetic resonance imaging (MRI) can also be used to quantify vessel cross-sectional area through a variety of measures including phase contrast angiography (Silber et al, 2001), highresolution cine bright-blood imaging (Wiesmann et al, 2004), and dynamic vessel wall imaging methods (Langham et al, 2013b). In addition to the measurement of vessel diameter needed for FMD quantification, these MRI methods, depending on the sequence used, can be used to evaluate the vessel wall or flow dynamics.…”

Section: Flow-mediated Dilation For Evaluation Of Endothelial Functionmentioning

confidence: 99%

“…A new approach to rapidly acquire high-resolution vessel-wall images to assess plaque burden in PAD have been modified to quantify superficial femoral artery FMD at 60, 90, and 120 s after cuff release (Langham et al, 2013b(Langham et al, , 2016. Of note is that the luminal FMD (denoted FMD L ), consisting of a measurement of the change in cross-sectional area (FMD L ≡ δA/A o ≈ 2δr/r o ), where δr and r 0 are the changes in radius, and radius at rest, respectively, yields greater detection sensitivity compared to ultrasound-based-measurement of the change in arterial diameter, i.e., FMD ≡ δd/d 0 = δr/r o .…”

Section: Flow-mediated Dilation For Evaluation Of Endothelial Functionmentioning

confidence: 99%

Quantitative and Dynamic MRI Measures of Peripheral Vascular Function

Englund

Langham

2020

Front. Physiol.

View full text Add to dashboard Cite

The endothelium regulates and mediates vascular homeostasis, allowing for dynamic changes of blood flow in response to mechanical and chemical stimuli. Endothelial dysfunction underlies many diseases and is purported to be the earliest pathologic change in the progression of atherosclerotic disease. Peripheral vascular function can be interrogated by measuring the response kinetics following induced ischemia or exercise. In the presence of endothelial dysfunction, there is a blunting and delay of the hyperemic response, which can be measured non-invasively using a variety of quantitative magnetic resonance imaging (MRI) methods. In this review, we summarize recent developments in non-contrast, proton MRI for dynamic quantification of blood flow and oxygenation. Methodologic description is provided for: blood oxygenationlevel dependent (BOLD) signal that reflect combined effect of blood flow and capillary bed oxygen content; arterial spin labeling (ASL) for quantification of regional perfusion; phase contrast (PC) to quantify arterial flow waveforms and macrovascular blood flow velocity and rate; high-resolution MRI for luminal flow-mediated dilation; and dynamic MR oximetry to quantify oxygen saturation. Overall, results suggest that these dynamic and quantitative MRI methods can detect endothelial dysfunction both in the presence of overt cardiovascular disease (such as in patients with peripheral artery disease), as well as in sub-clinical settings (i.e., in chronic smokers, non-smokers exposed to e-cigarette aerosol, and as a function of age). Thus far, these tools have been relegated to the realm of research, used as biomarkers of disease progression and therapeutic response. With proper validation, MRI-measures of vascular function may ultimately be used to complement the standard clinical workup, providing additional insight into the optimal treatment strategy and evaluation of treatment efficacy.

show abstract

“…However, peripheral artery angiography, [ 43 – 45 ] and the role in investigation of pulmonary hypertension, [ 46 ] vasculitis and systemic hypertension, [ 47 ] is also making progress. This is an area of CMR where contrast agents, [ 48 ] and 3 T has had an impact [ 49 , 50 ]. CMR is widely used for assessment of the aorta in both congenital, [ 51 ] genetic, [ 52 ] and acquired conditions and is particularly well suited longitudinal follow-up of aortic dimensions, [ 53 ] and more complex aspects of aortic function, [ 54 ] such as pulse wave velocity, [ 55 ] distensibility and shear stress [ 56 ].…”

Section: Atheroma Vascular Aorta Valvesmentioning

confidence: 99%

Review of Journal of Cardiovascular Magnetic Resonance 2014

Pennell¹,

Baksi²,

Prasad³

et al. 2015

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

There were 102 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2014, which is a 6 % decrease on the 109 articles published in 2013. The quality of the submissions continues to increase. The 2013 JCMR Impact Factor (which is published in June 2014) fell to 4.72 from 5.11 for 2012 (as published in June 2013). The 2013 impact factor means that the JCMR papers that were published in 2011 and 2012 were cited on average 4.72 times in 2013. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal’s impact over the last 5 years has been impressive. Our acceptance rate is <25 % and has been falling because the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality papers to JCMR for publication.

show abstract

Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo

Cited by 9 publications

References 29 publications

Pulse sequence programming in a dynamic visual environment: SequenceTree

Pulse sequence programming in a dynamic visual environment: SequenceTree

Quantitative and Dynamic MRI Measures of Peripheral Vascular Function

Review of Journal of Cardiovascular Magnetic Resonance 2014

Contact Info

Product

Resources

About