Vessel Wall Properties of Large Arteries in Uncomplicated IDDM

Mj, Kool; Lambert, J.; Cd, Stehouwer; Ap, Hoeks; Ha, Struijker Boudier; Bortel, Van

doi:10.2337/diacare.18.5.618

Cited by 94 publications

(70 citation statements)

References 34 publications

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“…17 The results of several studies, analysing the effect of DM on the arterial wall, are heterogeneous despite a general tendency toward an increase of the arterial stiffness in diabetics. 18 The mechanism of increased arterial stiffness relates to changes in elastin and collagen within the walls; the elastin fibres become fractured and collagen deposition is increased. Moreover, high glucose levels promote the formation of advanced glycation end-products, which has been associated with changes in the vessel walls.…”

Section: Discussionmentioning

confidence: 99%

Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness

et al. 2004

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“…23 However, compliance of the radial artery did not decrease, probably compensating for the loss of compliance in elastic arteries. 24 Compared to healthy subjects, in patients with (2) mild hypercholesterolemia 25 and in patients with (3) uncomplicated insulin-dependent diabetes mellitus, 26 arterial distensibility was lower at the femoral but not at the carotid artery. Studies on the effects of aging were mainly investigating central arteries in relatively small groups.…”

Section: Effect Of Aging On Large Artery Compliancementioning

confidence: 95%

Influence of aging on arterial compliance

Bortel

Spek

1998

J Hum Hypertens

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With aging, pulse pressure increases. A high pulse pressure has been recognised as an important cardiovascular risk factor. The increase in pulse pressure with aging is mainly due to a decrease in large artery compliance. Compliance and distensibility are large artery wall properties. Compliance is the buffering capacity of the vessel. Distensibility reflects much more the elasticity of the artery. Compliance is related to distensibility and arterial diameter. These large artery wall properties can be measured non-invasively using new echo-tracking techniques. With these techniques it has been shown that the elasticity (distensibility) and the buffering capacity (compliance) of the common carotid artery is decreasing with aging, while diameter of the artery increases. This increase in diameter might be a compen-

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“…4,5 Peripheral muscular arteries have been less well studied: results are variable, showing either unchanged brachial artery or increased radial artery stiffness in type 1 diabetes patients of mixed gender 21,22 or unchanged femoral artery stiffness in both males and females. 23 The behaviour of the brachial artery wall is of specific interest since it is often used as a model artery in the study of the endothelium, where dysfunction is suggested to precede atherogenesis.…”

Section: Discussionmentioning

confidence: 99%

Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus

Bjarnegård

Arnqvist

Lindström

et al. 2009

Diabetes and Vascular Disease Research

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O bservations of increased stiffness in the elastic aorta in women with diabetes, but not men, emphasise the need for further analysis regarding early abnormalities in arterial wall properties of women with type 1 diabetes mellitus (DM).Ultrasound was used to study the wall properties of the distal brachial artery (BA) in 37 type 1 diabetic women (aged 22-45 years) without evident complications and in 53 controls (C). Blood samples were drawn for later analysis.Flow-mediated dilatation (FMD) was slightly lower in DM than C, 8.1+4.3% vs. 10.3+4.9% (p<0.05), and nitrate-mediated dilatation (NMD) was markedly lower, 21.7+6.6% vs. 31.4+5.7% (p<0.001). Lumen diameter, intima-media thickness and distensibility were similar in DM and C. Insulin-like growth factor (IGF-1) was lower in DM than C, 231+65 vs. 349+68 ng/ml (p<0.001). Glycosylated haemoglobin (HbA 1C ) and matrix metalloproteinase (MMP-9) were independent predictors of the reduced NMD in the DM.Brachial artery responsiveness to an exogenous donor of nitric oxide (NO) was markedly reduced in type 1 diabetic women despite only limited reduction in endotheliumdependent dilatation. The negative association between NMD and HbA 1C suggests that long-term hyperglycaemia impairs vascular smooth muscle cell function in DM.

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Vessel Wall Properties of Large Arteries in Uncomplicated IDDM

Cited by 94 publications

References 34 publications

Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness

Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness

Influence of aging on arterial compliance

Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus

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