Vessel wall temperature estimation for novel short term thermal balloon angioplasty: study of thermal environment

Kaneko, Kenji; Nakatani, Eriko; Futami, Hikaru; Arai, Tsunenori; Fukui, Masao; Shimamura, S.; Kawabata, Takashi

doi:10.1109/iembs.2005.1616924

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…The depth of the collagen fiber stretched area became deeper to media with increasing the laser energy (Photographs are not shown in this manuscript). We have studied to develop a short-term (10-15s) heating balloon catheter to improve fundamental performance of balloon dilatation angioplasty, named "Photo-thermo dynamic balloon: PTDB" [9,10] . The experiment of the PTDB dilation of extracted porcine artery was performed.…”

Section: Stress-strain Curve Characteristicsmentioning

confidence: 99%

Ho:YAG laser irradiation in blood vessel as a vasodilator: ex vivo study

Nakatani

Iwasaki

Kaneko

et al. 2007

Photonic Therapeutics and Diagnostics III

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We studied Ho:YAG laser irradiation in blood vessel as a vasodilator ex vivo. We thought that the Ho:YAG laser-induced bubble expansion might be able to dilate the vessel because we found the vessel wall expansion after the Ho:YAG laser irradiation, that is steady deformation, in the vessel ex vivo. There have been many reports regarding to the Ho:YAG laser irradiation in the vessel. Most of studies concentrated on the interaction between Ho:YAG laser irradiation and vessel wall to investigate side effect on Ho:YAG laser angioplasty. We proposed to use the Ho:YAG laser-induced bubble expansion as a vasodilator. We studied vasodilation effect of the Ho:YAG laser-induced bubble ex vivo. The flash lamp excited Ho:YAG laser surgical unit (IH102, NIIC, Japan) ( =2.1µm) was used. The laser energy was delivered by a silica glass fiber (outer diameter: 1000µm, core diameter: 600µm). The laser-induced bubble was generated in the extracted fresh porcine carotid artery with the warmed saline perfusion. The laser energy at the fiber tip was ranging from 170-1300mJ per pulse. Number of the laser irradiation was ranged from 20pulses to 100pulses. The outer diameter of the vessel was observed. To examine the change in mechanical properties of the vessel wall, the stress-strain curve of the laser-irradiated vessel was measured. Birefringence observation and microscopic observation of staining specimen were performed. When the laser energy was set to 1300mJ per pulse, the outer diameter of the vessel after the laser irradiation was expanded by 1.4 times comparing with that of before the laser irradiation and the dilatation effect was kept even at 10minutes after the irradiation. The elasticity modulus of the artery by collagen was changed by the laser irradiation. In the polarized microscopic observation, the brightness of the intimal side of the vessel is increased comparing with that of the normal. We think this brightness increasing may be attributed to birefringence change by the arrangement of stretched collagen fiber. We suppose it is likely to be able to use the Ho:YAG laser irradiation as a temporary vasodilater tool in spite of further study should be performed.

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Section: Stress-strain Curve Characteristicsmentioning

confidence: 99%

Ho:YAG laser irradiation in blood vessel as a vasodilator: ex vivo study

Nakatani

Iwasaki

Kaneko

et al. 2007

Photonic Therapeutics and Diagnostics III

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The laser driven heating balloon catheter: Vessel dilatation characteristics

Shimazaki

Mizukami

Tokunaga

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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We studied on the dilatation characteristics of our new angioplasty, photo-thermo dynamic balloon (PTDB) angioplasty, which provides short-term heating (15s, 50-70 degrees C) dilatation by the combination of laser heat generator and fluid perfusion. In this study, we employed the ex vivo experiments to demonstrate the feasibility of our PTDB angioplasty with extracted porcine carotid artery. Balloon temperature and heating duration were easily controlled with the laser power and irradiation duration. Arterial dilatation was performed with the prototype PTDB catheter (3mm in diameter) ex vivo, sufficient dilation was attained with low dilatation pressure (2atm) that is lower than the limit pressure of elastic region (8atm in this case). The principal of our PTDB angioplasty that was based on the experimental results was dilatation in elastic region, while traditional POBA was accompanied with plastic deformation of artery. It is predicted that successful way of PTDB dilatation was attributed to collagen softening. Collagen coagulation and/or restructure after the heating dilatation might suspend the dilated arterial lumen. We demonstrated the feasibility of our PTDB angioplasty. We think collagen denaturation degree may be the important factor in this methodology.

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Vessel wall temperature estimation for novel short term thermal balloon angioplasty: study of thermal environment

Cited by 2 publications

References 5 publications

Ho:YAG laser irradiation in blood vessel as a vasodilator: ex vivo study

Ho:YAG laser irradiation in blood vessel as a vasodilator: ex vivo study

The laser driven heating balloon catheter: Vessel dilatation characteristics

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