Vestibular (Acoustic) Schwannomas: Histologic Features in Neurofibromatosis 2 and in Unilateral Cases

Sobel, Raymond A.; Wang, Youbin

doi:10.1097/00005072-199303000-00002

Cited by 113 publications

(72 citation statements)

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“…Cultured cells that diered in size may have originated from dierent regions within the tumor microenvironment. Consistent with this idea, schwannomas contain Antoni A and Antoni B regions, within which schwannoma cell histology and ultrastucture dier (Cravioto, 1969;Kawahara et al, 1988;Johnson et al, 1988;Wechsler and Hossman, 1965;Erlandson and Woodru, 1982;Sobel, 1993). Schwannoma cells of varying morphologies in culture have been noted previously (Cravioto and Lockwood, 1969).…”

Section: Discussionmentioning

confidence: 52%

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

et al. 1998

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Schwannomas are peripheral nerve tumors that typically have mutations in the NF2 tumor suppressor gene. We compared cultured schwannoma cells with Schwann cells from normal human peripheral nerves (NHSC). Both cell types expressed speci®c antigenic markers, interacted with neurons, and proliferated in response to glial growth factor, con®rming their identity as Schwann cells. Schwannoma cells frequently had elevated basal proliferation compared to NHSC. Schwannoma cells also showed spread areas 5 ± 7-fold greater than NHSC, aberrant membrane ruing and numerous, frequently disorganized stress ®bers. Dominant negative Rac inhibited schwannoma cell ruing but had no apparent eect on NHSC. Schwannoma cell stress ®bers were inhibited by C3 transferase, tyrphostin A25, or dominant negative RhoA. These data suggest that the Rho and Rac pathways are abnormally activated in schwannoma cells. Levels of ezrin and moesin, proteins related to the NF2 gene product, merlin, were unchanged in schwannoma cells compared to NHSC. Our ®ndings demonstrate for the ®rst time that cell proliferation and actin organization are aberrant in schwannoma cells. Because NF2 is mutant in most or all human schwannomas, we postulate that loss of NF2 contributes to the cell growth and cytoskeletal dysfunction reported here.

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Section: Discussionmentioning

confidence: 52%

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

et al. 1998

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“…In contrast, unilateral acoustic neuromas infrequently display a lobular pattern, normally have lower cellularity and abnormal vasculature, and are not associated with meningiomas. 10 In the case reported herein, our patient's tumor demonstrated characteristics common to both unilateral and NF2-associated acoustic neuromas. The tumor was noted to have high cellularity and meningeal growth, characteristics consistent with NF2.…”

Section: Commentmentioning

confidence: 53%

“…11,12 However, 1 series of NF2-associated acoustic neuromas found 10 of 48 samples containing discrete meningeal proliferations or small foci of meningeal growths within the schwannomas. 10 The scarcity of cases within the literature describing mixed Schwann-meningeal tumors may be the result of the difficulty in identifying these mixed tumors. Of the 10 mixed tumors that were identified histopathologically in the aforementioned series, only 3 could be identified grossly.…”

Section: Commentmentioning

confidence: 99%

“…20,[28][29][30][31][32] Mixed acoustic neuromas have predominantly been found in association with NF2. [10][11][12][13][14][15][16][17][18] The NF2 acoustic neuromas exhibit a predilection for histologic features not normally seen in unilateral, sporadic acoustic neuromas. Neurofibromatosis 2-associated acoustic neuromas more commonly show a lobular pattern, higher cellularity, and an association with meningeal proliferation.…”

Section: Commentmentioning

confidence: 99%

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Cerebellopontine Angle Tumor Composed of Schwann and Meningeal Proliferations

Chen

Samy²,

Gantz³

2001

Arch Otolaryngol Head Neck Surg

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Tumors found in the cerebellopontine angle are predominantly vestibular schwannomas. Mixed tumors found within the cerebellopontine angle are thought to be exceedingly rare and exclusively associated with neurofibromatosis 2. We report a case of a mixed tumor composed of Schwann and meningeal cell proliferations in a patient who was not diagnosed as having neurofibromatosis 2. Mixed tumors composed of neoplastic Schwann and meningeal cells have rarely been reported. However, new evidence indicates that these mixed tumors may be more common than was previously thought and may have an interrelated mechanism of pathogenesis. Although the case we describe does not fulfill the current diagnostic criteria for neurofibromatosis 2, a presumptive diagnosis was given, suggesting that the current diagnostic criteria for neurofibromatosis 2 may be too narrow.

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“…About 40% of NF2 vestibular tumors have a lobular pattern that is uncommon in tumors from individuals who have no known family history of NF2. 47 • NF2-associated vestibular schwannomas tend to be more invasive and to have a higher degree of dividing cells than non-NF2 tumors. They also tend to be multifocal.…”

Section: Histopathologymentioning

confidence: 99%

Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]

Evans

2009

Genetics in Medicine

120

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Vestibular (Acoustic) Schwannomas: Histologic Features in Neurofibromatosis 2 and in Unilateral Cases

Cited by 113 publications

References 0 publications

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

Cerebellopontine Angle Tumor Composed of Schwann and Meningeal Proliferations

Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]

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