Vestibular-evoked myogenic potentials in miniature pigs

Su, Xi; Yan, Zhang; Li, Ya; Qiu, Shuo; Zhang, Shili; Li, Yaohan; Ni, Yuan; Qiao, Yuehua; Yang, Shiming

doi:10.1016/j.joto.2016.05.003

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Negishi-Oshino et al used neck extensor muscle cVEMPs, in addition to behavioral rotarod, beam crossing, and air-righting reflex tests in adult C57BL/6J mice to measure IDPN vestibulotoxicity and thereby create an in vivo model of adult mammalian vestibular dysfunction ( 47 ). Finally, neck extensor muscle VEMPs have been studied in mini-pigs and rats ( 48 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

“…Negishi-Oshino et al used neck extensor muscle cVEMPs, in addition to behavioral rotarod, beam crossing, and airrighting reflex tests in adult C57BL/6J mice to measure IDPN vestibulotoxicity and thereby create an in vivo model of adult mammalian vestibular dysfunction (47). Finally, neck extensor muscle VEMPs have been studied in mini-pigs and rats (48,49). On post-SSCD day 1 in the small (1 mm) group, there was a small increase in latency, and the amplitude of the c+VEMP response was greatly decreased along with an increase in the stretch reflex.…”

Section: Imagingmentioning

confidence: 99%

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New model of superior semicircular canal dehiscence with reversible diagnostic findings characteristic of patients with the disorder

Wackym

Balaban²,

Osch³

et al. 2023

Front. Neurol.

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BackgroundThird window syndrome is a vestibular-cochlear disorder in humans in which a third mobile window of the otic capsule creates changes to the flow of sound pressure energy through the perilymph/endolymph. The nature and location of this third mobile window can occur at many different sites (or multiple sites); however, the most common third mobile window is superior semicircular canal dehiscence (SSCD). There are two essential objective diagnostic characteristics needed to validate a model of SSCD: the creation of a pseudoconductive hearing loss and cVEMP increased amplitude and decreased threshold.MethodsAdult Mongolian gerbils (n = 36) received surgical fenestration of the superior semicircular canal of the left inner ear. ABR and c+VEMP testing were carried out prior to surgery and over acute (small 1 mm SSCD, 1–10 days) or prolonged (large 2 mm SSCD, 28 days) recovery. Because recovery of function occurred quickly, condenser brightfield stereomicroscopic examination of the dehiscence site was carried out for the small SSCD animals post-hoc and compared to both ABRs and c+VEMPs. Micro-CT analysis was also completed with representative samples of control, day 3 and 10 post-SSCD animals.ResultsThe SSCD created a significant worsening of hearing thresholds of the left ear; especially in the lower frequency domain (1–4 kHz). Left (EXP)/right (CTL) ear comparisons via ABR show significant worsening thresholds at the same frequency representations, which is a proxy for the human pseudoconductive hearing loss seen in SSCD. For the c+VEMP measurements, increased amplitude of the sound-induced response (N1 2.5 ms and P1 3.2 ms) was observed in animals that received larger fenestrations. As the bone regrew, the c+VEMP and ABR responses returned toward preoperative values. For small SSCD animals, micro-CT data show that progressive osteoneogenesis results in resurfacing of the SSCD without bony obliteration.ConclusionThe large (2 mm) SSCD used in our gerbil model results in similar electrophysiologic findings observed in patients with SSCD. The changes observed also reverse and return to baseline as the SSCD heals by bone resurfacing (with the lumen intact). Hence, this model does not require a second surgical procedure to plug the SSCD.

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Section: Discussionmentioning

confidence: 99%

Section: Imagingmentioning

confidence: 99%

New model of superior semicircular canal dehiscence with reversible diagnostic findings characteristic of patients with the disorder

Wackym

Balaban²,

Osch³

et al. 2023

Front. Neurol.

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“…Masseter VEMP showed noticeably lower amplitudes when compared to cVEMP in both EMG-scaled and unscaled conditions. Studies on animals have also reported similar findings where the VEMPs recorded from neck extensor muscles exhibited higher amplitudes as compared to those recorded from the masseter muscle, while the latencies remained similar (Shi et al 32 ). The discrepancy in the peak-to-peak amplitude of cVEMP and mVEMP in the present study could have resulted due to the inherent difference in muscle mass between the masseter muscle and This article is protected by copyright.…”

Section: Accepted Manuscriptmentioning

confidence: 61%

Exploring the Relationship between Masseter and Cervical Vestibular-Evoked Myogenic Potentials in Young Adults with Hearing Thresholds Less Than or Equal to 15 dB HL

Vispute,

Neupane

2023

J Am Acad Audiol

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Background: Cervical vestibular evoked myogenic potentials (cVEMPs) and masseter vestibular evoked myogenic potentials (mVEMPs) are considered to have a common saccular origin. While a few studies have examined both VEMPs in individuals with brainstem disorders as part of a test battery, the relation between these two potentials has rarely been the subject of discussion. Purpose: The present study explored the relation between mVEMPs and cVEMPs using EMG-scaled parameters in normal-hearing young adults. Research Design: Within-subject study design Study Sample: Twenty young adults between 18 to 39 years of age (11 males, 9 females) participated in the study. Data Collection and Analysis: cVEMP and mVEMP were performed on all the participants at 95dBnHL with 500Hz tone burst stimuli. Various VEMP parameters were evaluated including P13 and N23 peak latencies, the amplitude of the P13-N23 complex, and the Interaural Amplitude Asymmetry Ratio (IAAR) in EMG-scaled and unscaled conditions. Results: All participants exhibited a 100% response rate for cVEMP and mVEMP responses. There were no significant ears and gender effect for both cVEMP and mVEMP. No correlation was found between cVEMP and mVEMP. There was no significant difference found between P1 and N1 latency values of cVEMP and mVEMP; however, a significant variation was observed for peak to peak amplitude both in EMG scaled and unscaled conditions between cVEMP and mVEMP. Conclusions: Minimal to no association between any parameters of cVEMPs and mVEMPs suggests no significant relationship between these two VEMPs.

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“…For the VEMP test, pigs were anesthetized with 3% pentobarbital sodium (1 ml/kg) and Sumianxin II (0.1 ml/kg). As the masseter muscles are easier to be surgically exposed than the neck extensor muscles, we recorded the response of masseter muscles for VEMP test [21]. VEMP response was elicited by open field sound stimuli.…”

Section: Methodsmentioning

confidence: 99%

Degeneration of saccular hair cells caused by MITF gene mutation

Du¹,

Ren²,

Jiang³

et al. 2019

Neural Dev

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BackgroundWaardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. Patients with WS may also experience primary vestibular symptoms. Most of the current WS studies did not discuss the relationship between WS and abnormal vestibular function. Our study found that a spontaneous mutant pig showed profound hearing loss and depigmentation. MITF-M, a common gene mutation causes type WS which affect the development of the intermediate cell of SV, was then identified for animal modeling.ResultsIn this study, the degeneration of vestibular hair cells was found in pigs with MITF-M. The morphology of hair cells in vestibular organs of pigs was examined using electron microscopy from embryonic day E70 to postnatal two weeks. Significant hair cell loss in the mutant saccule was found in this study through E95 to P14. Conversely, there was no hair cell loss in either utricle or semi-circular canals.ConclusionsOur study suggested that MITF-M gene mutation only affects hair cells of the saccule, but has no effect on other vestibular organs. The study also indicated that the survival of cochlear and saccular hair cells was dependent on the potassium release from the cochlear SV, but hair cells of the utricle and semi-circular canals were independent on SV.

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Vestibular-evoked myogenic potentials in miniature pigs

Cited by 3 publications

References 9 publications

New model of superior semicircular canal dehiscence with reversible diagnostic findings characteristic of patients with the disorder

New model of superior semicircular canal dehiscence with reversible diagnostic findings characteristic of patients with the disorder

Exploring the Relationship between Masseter and Cervical Vestibular-Evoked Myogenic Potentials in Young Adults with Hearing Thresholds Less Than or Equal to 15 dB HL

Degeneration of saccular hair cells caused by MITF gene mutation

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