Vestibular Function in Psoriasis Patients

Kınar, Abdullah; Bucak, Abdulkadir; Ulu, Şahin; Duman, Nilay; Baştuğ, Nur Betül

doi:10.1177/0145561320970683

Cited by 3 publications

(10 citation statements)

References 9 publications

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“…The inflammation cascade reactions may be involved in the pathogenesis of the otolith organ ( 31 ). The inner ear has a blood-labyrinth barrier, is connected to the cervical lymph nodes, and produces cytokines through the spiral ligament to participate in the inflammatory response ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo

Xie

Chen²,

Liu³

et al. 2022

Front. Neurol.

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ObjectiveThe present study aimed to determine whether residual dizziness (RD) after successful repositioning treatment in benign paroxysmal positional vertigo (BPPV) patients could be predicted by red blood cell distribution width (RDW).Materials and methodsIn this study, a total of 303 BBPV patients hospitalized at the neurology department were investigated. The enrolled patients were divided into two groups after successful repositioning treatment: non-RD group included patients who were completely cured, and RD group included patients with RD. We collected data on all subjects, including general information, blood routine examination, blood biochemical examination, and magnetic resonance imaging tests.ResultsThe mean RDW values of patients in the RD group were significantly higher than that in the non-RD group (13.63 ± 1.8 vs. 12.5 ± 0.8; p < 0.001). In subsequent multivariate analysis, elevated RDW levels were a statistically significant risk factor associated with the occurrence of RD [odds ratio = 2.62, 95% confidence interval (CI) 1.88–3.64, p < 0.001]. The area under the ROC curve was 0.723 in terms of its predictive ability to distinguish patients with RD. A cut-off point of 12.95% of RDW predicted RD with a sensitivity of 75.6% and a specificity of 69.5%. Moreover, the AUC for the ability of the RDW to predict recurrence were 0.692 (95% CI = 0.561–0.831; p < 0.014).ConclusionsElevated RDW level was related to increased risk of RD among BPPV patients, requiring further efforts to clarify the actual underlying pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Elevated red cell distribution width predicts residual dizziness in patients with benign paroxysmal positional vertigo

Xie

Chen²,

Liu³

et al. 2022

Front. Neurol.

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“…The highest risk of bias was present in Bias in selection of participants into the study. The funnel plot demonstrated all points except one lying within the funnel, indicating little to no publication bias (Supplemental Figure 2 Pure-Tone Audiometry Eight studies (29,34,36,37,(39)(40)(41)43) were included in the analysis of pure-tone audiometry testing at different frequencies (250 Hz, 500 Hz, 1 kHz, 2 kHz, 4 kHz, and 8 kHz) (Fig. 2A).…”

Section: Overall Study Characteristicsmentioning

confidence: 99%

“…Five studies (29,34,36,39,40) were included in the analysis of distortion product otoacoustic emission (DPOAE) results at different frequencies (1, 1.5, 2, 3, 4, and 6 kHz; Fig. 2C).…”

Section: Distortion Product Otoacoustic Emissionmentioning

confidence: 99%

“…Acknowledgments: The authors are indebted to Dr. Abdullah Kinar, M.D., Afyonkarahisar State Hospital Department of Neurology, for providing them with standard deviations for DPOAE data (40).…”

mentioning

confidence: 99%

“…LOE indicates level of evidence; SD, standard deviation. studies(33,35,(38)(39)(40)44). Eight studies(32,34,35,(37)(38)(39)(40)(41) reported PASI scores, and only two(37,41) reported BSA scores.…”

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confidence: 99%

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Otologic Manifestations of Psoriasis: A Systematic Review and Meta-Analysis

et al. 2022

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Introduction: Psoriatic skin lesions are often seen in the auricle and external auditory canal, but middle ear and inner ear manifestations are not easily identified. Several studies have indicated hearing loss and vestibular dysfunction with psoriasis, but the extent of association has not been well defined. Methods: A systematic search of PubMed, CINAHL, Scopus, and Cochrane Library was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies described audiometric or vestibular assessment of psoriasis patients. Meta-analysis was represented with odds ratios (ORs) or mean difference (MD) with 95% confidence intervals. Results: A total of 13 studies with 589 psoriasis patients and 617 healthy controls were included. Age did not significantly differ between psoriasis patients (47.1 [12.4] yr) and healthy controls (45.4 [11.2] yr). Psoriasis area and severity index score was 9.9 (8.4), and body surface area scores was 7.9 (14.7). Pure-tone audiometry analysis showed higher mean hearing thresholds in psoriasis patients compared with healthy controls across all frequencies, with the greatest difference at 4000 Hz (MD,; p < 0.00001). Speech reception thresholds were worse with psoriasis (MD,; p < 0.0001). Abnormal stapedial reflex was more common in psoriasis (OR,; p = 0.004). Abnormal vestibular testing was more common in psoriasis for caloric testing (OR,; p < 0.0001). Two additional studies of 41,681 psoriasis patients and 80,273 healthy controls found that psoriasis patients were at higher risk for sudden sensorineural hearing loss (OR,; p < 0.0001). Conclusion:Our study shows that psoriasis is associated with hearing loss and vestibular dysfunction, but clinical significance remains undefined. The trends noted in our study require more investigation, and the pathophysiologic mechanisms need to be defined.

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