Vestibular migraine

Radtke, A.; Brevern, Michael von; Neuhauser, Hannelore; Hottenrott, Tilman; Lempert, Thomas

doi:10.1212/wnl.0b013e31826e264f

Cited by 195 publications

(204 citation statements)

References 39 publications

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“…Episodic vasospasm can lead to hypo perfusion of the peripheral vestibular system and subsequent damage. Radtke et al 19 have followed 61 patients with definite vestibular migraine and have found that 15% of initial concomitant cochlear symptoms have risen to 49% during follow-up. In a multi-variant epidemiological study, Lempert et al 20 have found that age, hyperlipidemia, hypertension and migraine represent risk factor for BPPV but they did not find any association between BPPV and other well established risk factors like diabetes, obesity and smoking.…”

Section: Discussionmentioning

confidence: 99%

Clinical aspects of benign paroxysmal positional vertigo associated with migraine

Yetışer¹,

Gokmen²

2015

The International Tinnitus Journal

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Section: Discussionmentioning

confidence: 99%

Clinical aspects of benign paroxysmal positional vertigo associated with migraine

Yetışer¹,

Gokmen²

2015

The International Tinnitus Journal

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“…In one study, the VM patient group was longitudinally followed for 9 years and it was reported that the rate of cochlear symptoms in these patients was increased from 15% to 49% as time went by. It was also noted that half of the patients had cochlear symptoms with vertigo attacks and that seven of the patients developed bilateral hearing loss during the follow-up period (24).…”

Section: Discussionmentioning

confidence: 97%

Comparison of Audiological Findings in Patients with Vestibular Migraine and Migraine

Kırkım

Mutlu

Olgun

et al. 2017

Turk Arch Otorhinolaryngol

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Objective: The aim of this study was to investigate and compare the auditory findings in vestibular migraine (VM) and migraine patients without a history of vertigo. Methods:This study was conducted on 44 patients diagnosed with definite VM and 31 patients diagnosed with migraine who were followed and treated between January 2011 and February 2015. Also, 52 healthy subjects were included in this study as a control group. All participants underwent a detailed otorhinolaryngological examination followed by audiological evaluation, including pure tone audiometry, speech reception threshold, speech recognition score, and acoustic immitancemetry. Results:In the VM group, there were 16 patients (36.4%) with tinnitus, while in the other groups we did not observe any patients with tinnitus. The rate of tinnitus in the VM group was significantly higher in comparison to other groups (p<0.05). None of the groups had any patients with permanent or fluctuating sensorineural hearing loss. Conclusion:We conclude that patients with VM should be closely and longitudinally followed up for the early detection of other otological symptoms and possible occurrence of sensorineural hearing loss in the long term.

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“…32 In addition, there have been previous reports of sudden hearing loss and migraine in Meniere's disease. [33][34][35][36] However, the hearing loss developed in migraine patients at an older age, and their family members did not have hearing loss. Thus, it has not been clear whether the migraine and hearing loss share the same pathogenic cause in these cases.…”

Section: Discussionmentioning

confidence: 99%

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

Baek

Weigand

et al. 2014

Eur J Hum Genet

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Hereditary sensorineural hearing loss is an extremely clinical and genetic heterogeneous disorder in humans. Especially, syndromic hearing loss is subdivided by combinations of various phenotypes, and each subtype is related to different genes. We present a new form of progressive hearing loss with migraine found to be associated with a variant in the ATP1A2 gene. The ATP1A2 gene has been reported as the major genetic cause of familial migraine by several previous studies. A Korean family presenting progressive hearing loss with migraine was ascertained. The affected members did not show any aura or other neurologic symptoms during migraine attacks, indicating on a novel phenotype of syndromic hearing loss. To identify the causative gene, linkage analysis and whole-exome sequencing were performed. A novel missense variant, c.571G4A (p.(Val191Met)), was identified in the ATP1A2 gene that showed co-segregation with the phenotype in the family. In silico studies suggest that this variant causes a change in hydrophobic interactions and thereby slightly destabilize the A-domain of Na þ /K þ -ATPase. However, functional studies failed to show any effect of the p.(Val191Met) substitution on the catalytic rate of this enzyme. We describe a new phenotype of progressive hearing loss with migraine associated with a variant in the ATP1A2 gene. This study suggests that a variant in Na þ /K þ -ATPase can be involved in both migraine and hearing loss.

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Vestibular migraine

Cited by 195 publications

References 39 publications

Clinical aspects of benign paroxysmal positional vertigo associated with migraine

Clinical aspects of benign paroxysmal positional vertigo associated with migraine

Comparison of Audiological Findings in Patients with Vestibular Migraine and Migraine

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine

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