Vestibular responses to direct stimulation of the human insular cortex

Mazzola, Laure; Lopez, Christophe; Faillenot, Isabelle; Chouchou, Florian; Mauguı̀ere, François; Isnard, Jean

doi:10.1002/ana.24252

Cited by 69 publications

(52 citation statements)

References 67 publications

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“…Interestingly, the pattern of functional connectivity from the TPJ to the insula and the supplementary motor area varied during visuo-tactile stimulation, and reflected experimentallyinduced changes in self-location and first-person perspective. The involvement of the insula in BSC and self-location is in line with the prominent involvement of the insula neurons in the processing of bodily multisensory signals (Craig, 2002(Craig, , 2009Critchley, 2004;Critchley et al, 2004), including vestibular signals (Indovina et al, 2005;Mazzola et al, 2014). The insula is also the primary region processing interoceptive signals (Craig, 2002;Critchley et al, 2004) and has recently been shown to mediate changes in self-identification and self-location based on cardio-visual stimulation in the full-body illusion (Aspell et al, 2013;Ronchi et al, 2015), illusory own-body perceptions due to interoceptive-exteroceptive disintegration in neurological patients and hand ownership (Tsakiris et al, 2007).…”

Section: Self-face Perception and Face Ownershipmentioning

confidence: 55%

Behavioral, Neural, and Computational Principles of Bodily Self-Consciousness

Blanke

Slater

Serino

2015

Neuron

595

510

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Recent work in human cognitive neuroscience has linked self-consciousness to the processing of multisensory bodily signals (bodily self-consciousness [BSC]) in fronto-parietal cortex and more posterior temporo-parietal regions. We highlight the behavioral, neurophysiological, neuroimaging, and computational laws that subtend BSC in humans and non-human primates. We propose that BSC includes body-centered perception (hand, face, and trunk), based on the integration of proprioceptive, vestibular, and visual bodily inputs, and involves spatio-temporal mechanisms integrating multisensory bodily stimuli within peripersonal space (PPS). We develop four major constraints of BSC (proprioception, body-related visual information, PPS, and embodiment) and argue that the fronto-parietal and temporo-parietal processing of trunk-centered multisensory signals in PPS is of particular relevance for theoretical models and simulations of BSC and eventually of self-consciousness.

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Section: Self-face Perception and Face Ownershipmentioning

confidence: 55%

Behavioral, Neural, and Computational Principles of Bodily Self-Consciousness

Blanke

Slater

Serino

2015

Neuron

595

510

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“…The stereotactic implantation followed the procedure described in our previous studies (Mazzola et al, ; Mazzola et al, ; Mazzola, Isnard, & Mauguière, ). Electrodes were implanted perpendicular to the midsagittal plane and were left in place chronically up to 15 days.…”

Section: Methodsmentioning

confidence: 99%

How the insula speaks to the heart: Cardiac responses to insular stimulation in humans

Chouchou¹,

Mauguı̀ere

Vallayer

et al. 2019

Human Brain Mapping

Self Cite

108

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Despite numerous studies suggesting the role of insular cortex in the control of autonomic activity, the exact location of cardiac motor regions remains controversial. We provide here a functional mapping of autonomic cardiac responses to intracortical stimulations of the human insula. The cardiac effects of 100 insular electrical stimulations into 47 epileptic patients were divided into tachycardia, bradycardia, and no cardiac response according to the magnitude of RR interval (RRI) reactivity. Sympathetic (low frequency, LF, and low to high frequency powers ratio, LF/HF ratio) and parasympathetic (high frequency power, HF) reactivity were studied using RRI analysis. Bradycardia was induced by 26 stimulations (26%) and tachycardia by 21 stimulations (21%). Right and left insular stimulations induced as often a bradycardia as a tachycardia. Tachycardia was accompanied by an increase in LF/HF ratio, suggesting an increase in sympathetic tone; while bradycardia seemed accompanied by an increase of parasympathetic tone reflected by an increase in HF. There was some left/right asymmetry in insular subregions where increased or decreased heart rates were produced after stimulation. However, spatial distribution of tachycardia responses predominated in the posterior insula, whereas bradycardia sites were more anterior in the median part of the insula. These findings seemed to indicate a posterior predominance of sympathetic control in the insula, whichever the side; whereas the parasympathetic control seemed more anterior. Dysfunction of these regions should be considered when modifications of cardiac activity occur during epileptic seizures and in cardiovascular diseases.

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“…Finally, temporopolar cortex, although relatively poorly understood as a region, is hypothesized to act as a “paralimbic” area working closely with more canonical limbic areas . Temporopolar cortex shows dense anatomical interconnections to OFC, the insula, the amygdala, and other medial temporal lobe structures . A proposed role of this region is in binding visceral‐affective assessments with highly processed perceptual information—that is, integrating affect with perception, presumably in the service of higher order decision making .…”

Section: Affect In the Self‐generated Thought Of Healthy Populationsmentioning

confidence: 99%

Affective neuroscience of self‐generated thought

Fox

Andrews‐Hanna

Mills

et al. 2018

Annals of the New York Academy of Sciences

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Despite increasing scientific interest in self-generated thought-mental content largely independent of the immediate environment-there has yet to be any comprehensive synthesis of the subjective experience and neural correlates of affect in these forms of thinking. Here, we aim to develop an integrated affective neuroscience encompassing many forms of self-generated thought-normal and pathological, moderate and excessive, in waking and in sleep. In synthesizing existing literature on this topic, we reveal consistent findings pertaining to the prevalence, valence, and variability of emotion in self-generated thought, and highlight how these factors might interact with self-generated thought to influence general well-being. We integrate these psychological findings with recent neuroimaging research, bringing attention to the neural correlates of affect in self-generated thought. We show that affect in self-generated thought is prevalent, positively biased, highly variable (both within and across individuals), and consistently recruits many brain areas implicated in emotional processing, including the orbitofrontal cortex, amygdala, insula, and medial prefrontal cortex. Many factors modulate these typical psychological and neural patterns, however; the emerging affective neuroscience of self-generated thought must endeavor to link brain function and subjective experience in both everyday self-generated thought as well as its dysfunctions in mental illness.

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Vestibular responses to direct stimulation of the human insular cortex

Cited by 69 publications

References 67 publications

Behavioral, Neural, and Computational Principles of Bodily Self-Consciousness

Behavioral, Neural, and Computational Principles of Bodily Self-Consciousness

How the insula speaks to the heart: Cardiac responses to insular stimulation in humans

Affective neuroscience of self‐generated thought

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