Veterinary allergy diagnosis: past, present and future perspectives

Martins, Luís; Bento, Ofélia; Inácio, Filipe

doi:10.1007/s40629-016-0135-z

Cited by 3 publications

(2 citation statements)

References 89 publications

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“…Allergic contact dermatitis is a multifactorial inflammatory skin disease in both humans and dogs. The involved factors that contribute to the condition include genetics, environment, pharmaceutical agents, epidermal skin and immunological factors (Ho et al., 2015 ; Martins et al., 2016 ). Deviation of Th cell balance and harmonizing regulatory T cells are the main mechanisms through which probiotics affect immune responses (De Roock et al., 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs

Khosravi,

Avizeh,

Zayerzadeh

et al. 2024

Veterinary Medicine & Sci

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BackgroundProbiotic strains have the potential to modulate immune responses, reduce intestinal inflammation, normalize intestinal mucosal function and decrease allergic reactions.ObjectiveThis study aimed to investigate the effect of oral probiotic supplements containing Bacillus subtilis and Bacillus coagulans spores on clinical symptoms, haematological factors and immune responses to allergic contact dermatitis in dogs induced by dinitrochlorobenzene (DNCB).MethodsDNCB was injected subcutaneously into the scapular region of 20 healthy adult dogs of both sexes, divided into four groups, to induce experimental allergic contact dermatitis. Dogs in Group 1 received food without probiotics or medication. Oral prednisolone was administered to Group 2 for 30 days at a dosage of 0.25 mg/kg every other day. The dogs in Group 3 were treated with a combination of oral prednisolone and probiotics. The dogs in Group 4 were fed daily with a mixture of 109 B. subtilis and B. coagulans bacteria for 30 days. The immune system responses and related gene expression were analysed in the treated animals.ResultsThe administration of probiotics for 30 days resulted in a reduction in clinical symptoms and duration of wound repair. The probiotics treatment also significantly increased the serum bactericidal effects against Staphylococcus aureus and Escherichia coli. It enhanced both the classic and alternative activity of the complement, as well as lysozyme activity. Additionally, the probiotics led to higher total immunoglobulin levels and significant reductions in anti‐trypsin and C‐reactive protein levels. Furthermore, the expression of IgE, induction of interferon‐gamma and IL‐4 genes were also reduced.ConclusionsAccording to the results, B. subtilis and B. coagulans can be further investigated as a viable alternative to corticosteroids in treating allergic contact dermatitis in dogs.

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Section: Discussionmentioning

confidence: 99%

Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs

Khosravi,

Avizeh,

Zayerzadeh

et al. 2024

Veterinary Medicine & Sci

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“…Despite this commensal frame without causing lesion, in presence of different factors like host´s innate and adaptive immune defenses and expression of cell wall and secreted virulence factors, Malassezia populations may overgrow, more or less severe inflammation, in a complex homeostatic equilibrium. This immune-mediated hyperreactivity configures the Malassezia dermatitis condition (62) which is rather common in dog allergic patients, even without confirmed hypersensitivity to Malassezia(70). Malassezia is commonly performed through intradermal and serology, although the lack of standardization of the available extracts turns it somehow unrealiable(62).…”

mentioning

confidence: 99%

Fungi in Veterinary Medicine: Alternaria, Dermatophytes and Malassezia Pay the Bill!

Martins¹

2022

Preprint

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Fungi kingdom comprises ubiquitous forms of life with 1.5 billion years, mostly phytopathogenic and commensal for humans and animals. However, in the presence of impaired conditions fungi may cause disease by intoxicating, infecting or sensitizing with allergy. Different genera may be implicated as etiological agents for humans and animals, with Alternaria, Aspergillus, dermatophytes like Microsporum and Trichophyton, and Malassezia as the commonly implicated. Alternaria and Malassezia stand as the most commonly associated to either allergy or infection, immediately followed by Aspergillus, while dermatophytes are usually associated to ring worm skin infection. Research in veterinary field is not much but necessary.

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Allergiediagnostik bei Hunden

Leiner¹

2016

Allergo J

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Veterinary allergy diagnosis: past, present and future perspectives

Cited by 3 publications

References 89 publications

Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs

Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs

Fungi in Veterinary Medicine: Alternaria, Dermatophytes and Malassezia Pay the Bill!

Allergiediagnostik bei Hunden

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