Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea

Kang, JeongWoo; Park, Hae-Chul; Gedi, Vinayakumar; Park, Sujeong; Kim, Myeong-Ae; Kim, Minkyoung; Kwon, Hyun-Jung; Cho, Byung-Hoon; Kim, Tae‐Wan; Lee, Kwang‐jick; Lim, Chae-Mi

doi:10.1080/19393210.2014.1001795

Cited by 19 publications

(14 citation statements)

References 8 publications

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“…Concentration of active ingredient is the most important characteristic of a drug product, as the amount of active ingredient allows to determine the intensities of treatment and toxicity of that particular drug. Moreover, the noncompliance rates of veterinary medicines are also pertaining in the elevation of contamination and drugs residues in the food products of animal origin [ 14 , 15 ]. The NPMS assessment was initiated in 1964 for the quality control of OCD which are in distribution.…”

Section: Discussionmentioning

confidence: 99%

National post-market surveillance assessment of veterinary medicines in Korea during the past decade

Kang¹,

Park²,

Jang³

et al. 2017

BMC Vet Res

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BackgroundVeterinary medicines have been widely used for the prevention and treatment of diseases, growth promotion, and to promote feeding efficacy in livestock. As the veterinary medicine industry has steadily grown, it is crucial to set up a baseline for the quality of medicine as well as the insufficiency or excessiveness of the active ingredients in drug products to ensure the compliance, safety and efficacy of these medicines. Thus, the 10 years data of post-marketing quality control study was summarized to determine the rate and extent of non-compliance of these medicines and to establish baseline data for future quality control measures of veterinary medicine.ResultsIn this study, 1650 drugs for veterinary use were collected per year from each city and province in Korea and analysed for the quantity of active ingredients according to the “national post-market surveillance (NPMS) system” over the past decade. The NPMS assessment was performed using liquid and gas chromatography, titration, UV/Vis spectrophotometry, and bioassays. A total of 358 cases were deemed noncompliant, with the average noncompliance rate for all medicine types being 2.0%. The average noncompliance rates for antibiotics, biologics and other chemical drugs except antibiotics (OCD) were 1.1%, 1.2%, and 3.0%, respectively. The first leading cause for noncompliant products was insufficient quantity of major ingredients (283 cases), and the second leading cause was the existence of excess amount of active ingredients (60 cases). Tylosin, spiramycin, ampicillin, tetracyclines and penicillins were most frequently found to be noncompliant among antibiotics. Among the OCD, the noncompliance was found commonly in vitamin A.ConclusionThe overall trend presented gradually decreasing violation rates, suggesting that the quality of veterinary medicines has improved. Consistent application of the NPMS assessment and the establishment of the Korea Veterinary Good Manufacturing Practice (KVGMP) will help to maintain the good quality of medicine.

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Section: Discussionmentioning

confidence: 99%

National post-market surveillance assessment of veterinary medicines in Korea during the past decade

Kang¹,

Park²,

Jang³

et al. 2017

BMC Vet Res

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“…Also, Gentili et al found no presence of PBZ in meat samples collected random from the Italian market. On the contrary, van Pamel et al found levels of 2 μg/kg for PBZ and 3.3 and 4.6 μg/kg for OXPBZ in horse meat samples, while Kang et al detected only 1 positive cattle liver sample at concentrations of 247 μg/kg and 15 μg/kg for PBZ and OXPBZ, respectively.…”

Section: Resultsmentioning

confidence: 94%

Investigation of phenylbutazone and its metabolite oxyphenbutazone in horse meat products during years 2013–2017

Annunziata

Visciano

Stramenga

et al. 2018

Drug Testing and Analysis

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This study showed the results of a monitoring program aimed at detecting the fraudulent use of horse meat in samples collected in the framework of official controls during the years 2013-2017 after the so-called horse meat scandal that caused a decreasing consumer confidence in the food industry, particularly in meat products. A total of 125 samples diversely distributed in the 5 years of monitoring were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The method was validated according to Commission Decision 657/2002/EC with regard to the following parameters: linearity, specificity, decision limit (CCα), detection capability (CCβ), recovery, and precision (repeatability and within-laboratory reproducibility). Even if the results of this study revealed no positive sample, the need for constant assurance of food safety and consumers' health protection requires the implementation of preventive as well as corrective actions in the management of risks linked to the food chain in a more global context.

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“…The APQA implements a post‐production quality control system of collection and inspection of circulating veterinary drugs in order to prevent the production and distribution of low‐quality drugs (MAFRA (Ministry of Agriculture, Food, and Rural Affairs), 2017b; Kang et al., 2015; Kang, et al., 2017). The products included in these inspections are mostly those with high volumes of sales or those that have consistently shown high rates of noncompliance.…”

Section: Discussionmentioning

confidence: 99%

Surveillance assessment for veterinary biocidal products in Korea: A laboratory investigation

Kang

Hossain

Park

et al. 2020

Veterinary Medicine & Sci

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Veterinary biocides used in animal husbandry have the potential to cause human health concerns. Biocidal products for veterinary use, which contain pesticides approved in Korea, comprise 49 active ingredients within 234 products. Within 17 of these products there are 3 ingredients which are highly hazardous pesticides: coumaphos, dichlorvos and methomyl. In this study, the content of the active ingredients of 160 products sold domestically was investigated. Samples were collected for 119 biocidal products for veterinary use. These were analysed by high‐performance liquid chromatography (HPLC) and gas chromatography (GC). Seventeen products were noncompliant (insufficient or excess quantity of active ingredients). The ingredients that were below the stated concentrations were amitraz, chlorpyrifos‐methyl, cypermethrin, cyromazine, dichlorvos, fipronil, muscamone and trichlorfon. The ingredients that exceeded the stated concentrations were abamectin, fluvalinate and pyriproxyfen. The noncompliance rate in biocidal products for veterinary use was 9.19%. The results of this study show that three highly hazardous pesticides (coumaphos, dichlorvos and methomyl) and 10 active ingredients (abamectin, amitraz, chlorpyrifos‐methyl, cypermethrin, cyromazine, fipronil, fluvalinate, muscamone, pyriproxyfen and trichlorfon) deviated from the stated concentrations. Thus, management plans should be established to ensure compliant veterinary drugs by post‐distribution quality control, such as planning for regular inspection.

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Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea

Cited by 19 publications

References 8 publications

National post-market surveillance assessment of veterinary medicines in Korea during the past decade

National post-market surveillance assessment of veterinary medicines in Korea during the past decade

Investigation of phenylbutazone and its metabolite oxyphenbutazone in horse meat products during years 2013–2017

Surveillance assessment for veterinary biocidal products in Korea: A laboratory investigation

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