1912
DOI: 10.1098/rstb.1912.0006
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VI. Further experiments upon the blood volume of mammals and its relation to the surface area of the body

Abstract: In previous papers* we have shown that the blood volume of normal and healthy mammals, such as rabbits, guinea-pigs, and mice, is satisfactorily expressed by the formula B = W n / k , where B is the blood volume in cubic centimetres, W the weight of the individual in grammes, n approximately ⅔, and k a constant (calculated from the experiments), which varies with the particular species of animal. This formula indica… Show more

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Cited by 19 publications
(6 citation statements)
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“…The ratio between these figures (3-27 and 17*34) is also almost exactly the same as that which was found between the corresponding figures in the case of the blood volume (2), although in that case the mean deviations themselves were much smaller (namely, 1*39 and 7'82 per cent, respectively), owing to the much greater intrinsic accuracy of the technique.…”
Section: ------------------------------supporting
confidence: 68%
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“…The ratio between these figures (3-27 and 17*34) is also almost exactly the same as that which was found between the corresponding figures in the case of the blood volume (2), although in that case the mean deviations themselves were much smaller (namely, 1*39 and 7'82 per cent, respectively), owing to the much greater intrinsic accuracy of the technique.…”
Section: ------------------------------supporting
confidence: 68%
“…But wherever observations covering a wide range of weight are concerned it is essential to make use of the " best n '' in order to obtain reliable results. In this connection it may be noted incidentally as a point of interest that the ratio between the deviations just quoted for n = -f and n = best n ,namely, 3*81 /2* practically identical with the corresponding ratio already given elsewhere (2) in the case of the blood volume, namely, 2,0 8 /l'39 (i.e. 1*5).…”
Section: ]mentioning
confidence: 82%
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“…The second, a work by Pinkel in 1958 (17), suggests a seemingly closer relationship for a reported therapeutic dose of 5 chemotherapeutic drugs between humans and 1‐3 of 4 selected species (rat, mouse, hamster, and 10 kg dog) when BSA scaling was used rather than by body weight scaling (17). Pinkel supports the claim that blood volume was scalable between species by BSA using works published by Dreyer and Ray in 1910 and in 1912 (18, 19), which were limited to comparisons among mice, guinea pigs, and rabbits (11, 17). Pinkel also cites work relating blood volume, plasma proteins, and glomerular filtration rate scaling by BSA between humans of various sizes, rather than between species.…”
Section: Brief History Of Bsa Scalingmentioning
confidence: 63%
“…Giving such high doses chronically may however have dire consequences. Small animals excrete compounds more rapidly than larger animals in a rather systematic manner, therefore studies conducted in animals would need dose adjustments when they are applied to humans 42,43 . A non-toxic dose in rats can be toxic to humans if safety factor is not accounted for.…”
Section: Discussionmentioning
confidence: 99%