2019
DOI: 10.1016/j.jevs.2019.02.019
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Viability of Equine Chondrocytes After Exposure to Mepivacaine and Ropivacaine In Vitro

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Cited by 12 publications
(14 citation statements)
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“…The MTT assay detects changes in cellular metabolism, namely the activity of mitochondrial reductases, whereas fluorescent labeling relies on membrane indicators of cellular viability. It is possible that early changes in cellular metabolism occur prior to changes in the plasma membrane that provide evidence of loss of viability 19 . The results of the two studies cited provide evidence that the MTT assay used in this study should be as sensitive as or more sensitive than fluorescent labeling and flow cytometry techniques when determining the in vitro chondrotoxic effects of bupivacaine 19,20 …”
Section: Discussionmentioning
confidence: 74%
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“…The MTT assay detects changes in cellular metabolism, namely the activity of mitochondrial reductases, whereas fluorescent labeling relies on membrane indicators of cellular viability. It is possible that early changes in cellular metabolism occur prior to changes in the plasma membrane that provide evidence of loss of viability 19 . The results of the two studies cited provide evidence that the MTT assay used in this study should be as sensitive as or more sensitive than fluorescent labeling and flow cytometry techniques when determining the in vitro chondrotoxic effects of bupivacaine 19,20 …”
Section: Discussionmentioning
confidence: 74%
“…It is possible that early changes in cellular metabolism occur prior to changes in the plasma membrane that provide evidence of loss of viability. 19 The results of the two studies cited provide evidence that the MTT assay used in this study should be as sensitive as or more sensitive than fluorescent labeling and flow cytometry techniques when determining the in vitro chondrotoxic effects of bupivacaine. 19,20 An unexpected result noted with LEB was that the short-term lack of toxicity was not replicated with longterm culture.…”
Section: Discussionmentioning
confidence: 75%
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