Viable Nematodes from Late Pleistocene Permafrost of the Kolyma River Lowland

Shatilovich, A. V.; Tchesunov, Alexei V.; Neretina, Tatyana V.; Grabarnik, I. P.; Губин, С. В.; Vishnivetskaya, Tatiana A.; Onstott, Tullis C.; Rivkina, Elizaveta

doi:10.1134/s0012496618030079

Cited by 48 publications

(57 citation statements)

References 4 publications

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“…: If a living organism were guaranteed a constant supply of nutrition, safety and elimination of wastes, it would have no incentive to do anything else. An agent in a dormant state (a virus, a seed or worms in natural cryopreservation [100]), could remain inactive indefinitely. The goals of biological agents appear to be a derivative of needs.…”

Section: Are Mutations Crossovers Aging and Death Necessary?mentioning

confidence: 99%

Facts and Anomalies to Keep in Perspective When Designing an Artificial Intelligence

Ipe¹

2020

Preprint

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Section: Are Mutations Crossovers Aging and Death Necessary?mentioning

confidence: 99%

Facts and Anomalies to Keep in Perspective When Designing an Artificial Intelligence

Ipe¹

2020

Preprint

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“…When searching for an alternative, we would do right to turn to Nature and see how longterm preservation has evolved there. A look around tells us that although some freezing instances do exist [23], by far and large long-term preservation in Nature is rather done by removing the water and thus bringing molecular interactions and metabolism to practical standstill. We know, however, that water is essential for life.…”

Section: Nature's Alternativementioning

confidence: 99%

Exploring dry storage as an alternative biobanking strategy inspired by Nature

Saragusty

Loi

2019

Theriogenology

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Close to 25% of species in the animal kingdom face the risk of extinction. A variety of stresses, largely anthropogenic in nature, and lack of sufficient resources and political support to counteract this biodiversity crisis, suggest that we will witness the extinction of many thousands of species in the coming years. Unless we act now to, at least, preserve samples from each and every threatened species, these extinct species will be lost forever. To preserve record of the world's biodiversity, establishment of genome resource banks is thus desirable. Presently, biobanking is done almost exclusively by cryopreservation, followed by maintenance of the samples under liquid nitrogen. Cryopreservation has satisfactory efficiency but it comes with a host of problems. The process is also highly species-specific. Like in many other walks of life, we can search Nature for better alternatives. When longterm preservation is desired, Nature opted for controlled drying rather than in water preservation via freezing. Nature also created an assortment of materials that protect organisms from damages during the drying and rehydration processes. Once dry, these organisms can survive extended periods of time and be resistant to extreme environmental stressors. Over the past 70 years researchers attempted applying this idea to preserved desiccation-sensitive mammalian cells in the dry form. Desiccation is experiencing increased interest in recent years with some exciting developments. Presented here an overview of dry preservation and its possible applications towards establishment of dry biobanks as part of our endeavour to preserve the world's biodiversity.

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“…At −20 • C tardigrades can survive for 30 years [132]. Also, the nematode Caenorhabditis elegans was reported to have been revitalized from 42,000-years-old Siberian permafrost [133].…”

Section: Spores and Survival Under Extreme Conditionsmentioning

confidence: 99%

Viroids-First—A Model for Life on Earth, Mars and Exoplanets

Moelling

Broecker

2019

Geosciences

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The search for extraterrestrial life, recently fueled by the discovery of exoplanets, requires defined biosignatures. Current biomarkers include those of extremophilic organisms, typically archaea. Yet these cellular organisms are highly complex, which makes it unlikely that similar life forms evolved on other planets. Earlier forms of life on Earth may serve as better models for extraterrestrial life. On modern Earth, the simplest and most abundant biological entities are viroids and viruses that exert many properties of life, such as the abilities to replicate and undergo Darwinian evolution. Viroids have virus-like features, and are related to ribozymes, consisting solely of non-coding RNA, and may serve as more universal models for early life than do cellular life forms. Among the various proposed concepts, such as “proteins-first” or “metabolism-first”, we think that “viruses-first” can be specified to “viroids-first” as the most likely scenario for the emergence of life on Earth, and possibly elsewhere. With this article we intend to inspire the integration of virus research and the biosignatures of viroids and viruses into the search for extraterrestrial life.

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Viable Nematodes from Late Pleistocene Permafrost of the Kolyma River Lowland

Cited by 48 publications

References 4 publications

Facts and Anomalies to Keep in Perspective When Designing an Artificial Intelligence

Facts and Anomalies to Keep in Perspective When Designing an Artificial Intelligence

Exploring dry storage as an alternative biobanking strategy inspired by Nature

Viroids-First—A Model for Life on Earth, Mars and Exoplanets

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