Manuel Vázquez Montalbán’s Pepe Carvalho detective novels comprise a seminal series, spanning eighteen novels from 1972 to 2004, that consolidated the novela negra as a popular, denunciatory genre in Spain. While much has been written about the early entries in the series, the latter novels, namely El hombre de mi vida (2000), Milenio I: Rumbo a Kabul, and Milenio II: En las antípodas (2004), have not received similar attention. Critics like Colmeiro, Balibrea, and Nichols have accurately read these novels as a denunciation of the most evident negative consequences of globalization at the turn of the new millennium, principally gentrification, displacement, and the exploitation of both labor and natural resources. Here, I expand this analysis to consider another of the deleterious effects of free-market rationality: The increasing personal alienation that has come to characterize modern neoliberal societies, a phenomenon recently analyzed by political philosophers like Brown (2015) and May (2012), and psychologists such as Verhaeghe (2014). I argue that, as the Carvalho character evolves throughout the series and neoliberalism achieves cultural hegemony, the depiction of the solitary protagonist in the final three novels denounces the growing isolation of the individual in a transnational society. This is reflected in the trope of the voyage, Carvalho’s nostalgic melancholia, and the progressively alienated condition of the marginalized detective as his relationships with others, tenuous in the best circumstances, begin to fully disintegrate.