Viaminate ameliorates Propionibacterium acnes-induced acne via inhibition of the TLR2/NF-κB and MAPK pathways in rats

Cao, Junjie; Xu, Meifeng; Zhu, Longfei; Xiao, Shengxiang

doi:10.1007/s00210-022-02379-0

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Studies have shown that C. acnes activates TLRs mainly by promoting the signal transduction of the NF-κB and MAPKs pathways to activate the expression of downstream in ammatory factors, chemokines, and MMPs genes. [33,34] We observed the nuclear displacement of YTCY-EPs on NF-κB and AP-1 by immuno uorescence staining, and detected the content of related conduction factors by Western blot and qRT-PCR. The results of these experiments show that, in the role of cells, YTCY-EPs can regulate the NF-κB and MAPKs pathways by regulating TLR2/TRAF6 to reduce the production of in ammatory factors, chemokines, and MMPs, thereby reducing or avoiding the development of acne in ammation problems.…”

Section: Discussionmentioning

confidence: 99%

Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6-Mediated NF-κB and MAPKs Signaling Pathways

Zhang,

Jiang,

Zhao

et al. 2023

Probiotics & Antimicro. Prot.

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As a probiotic, Weizmannia coagulans (W. coagulans) is often used in food and medicine to regulate intestinal ora and resist speci c in ammation. In this study, the anti-acne e cacy and mechanism of YTCY extracellular proteins (YTCY-EPs) from a strain of W. coagulans are analyzed. The main components of YTCY-EPs, extracted and separated from the fermentation broth, are peptides ranging from 1.51-11.44 kDa, accounting for about 80%. Among the peptides identi ed by LC/MS-MS, YTCY A-F possess the properties of antimicrobial peptides, while YTCY 1-4 possess antioxidative properties. These peptides have a strong effect on Cutibacterium acnes (C. acnes) and signi cantly inhibit Staphylococcus aureus. The adhesion of YTCY-EPs has a 50% inhibition rate. It is found that YTCY-EPs possess strong antioxidant and anti-in ammatory properties, and can reduce the downstream TLR2/NF-κB and MAPKs/AP-1 pathways by regulating the nuclear translocation of NF-κB and AP-1 in vitro. The transcriptional expression of in ammatory cytokines, in ammatory chemokines, and matrix metalloproteinase genes is also regulated, thereby slowing the recruitment of in ammatory cells and the development of in ammation, and increasing keratinocyte mobility. YTCY-EPs can also effectively solve such problems as erythema, papules, cysts, skin lesions, hyperkeratinization, and desquamation caused by C. acnes in rabbit ears. Additionally, the treatment effectively improves the condition of wounds and in ammation. The results of this study prove that YTCY-EPs can be used as a potential anti-acne raw material in cosmetics.

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Section: Discussionmentioning

confidence: 99%

Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6-Mediated NF-κB and MAPKs Signaling Pathways

Zhang,

Jiang,

Zhao

et al. 2023

Probiotics & Antimicro. Prot.

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The combination of RL-QN15 and OH-CATH30 to promotes the repair of acne via the TLR2/NF-κB pathway

Huang,

Liu,

et al. 2024

European Journal of Pharmacology

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Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6- Mediated NF-κB and MAPKs Signaling Pathways

Jiang

Zhao

et al. 2023

Preprint

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As a probiotic, Weizmannia coagulans (W. coagulans) is often used in food and medicine to regulate intestinal flora and resist specific inflammation. In this study, the anti-acne efficacy and mechanism of YTCY extracellular proteins (YTCY-EPs) from a strain of W. coagulans are analyzed. The main components of YTCY-EPs, extracted and separated from the fermentation broth, are peptides ranging from 1.51–11.44 kDa, accounting for about 80%. Among the peptides identified by LC/MS-MS, YTCY A-F possess the properties of antimicrobial peptides, while YTCY 1–4 possess antioxidative properties. These peptides have a strong effect on Cutibacterium acnes (C. acnes) and significantly inhibit Staphylococcus aureus. The adhesion of YTCY-EPs has a 50% inhibition rate. It is found that YTCY-EPs possess strong antioxidant and anti-inflammatory properties, and can reduce the downstream TLR2/NF-κB and MAPKs/AP-1 pathways by regulating the nuclear translocation of NF-κB and AP-1 in vitro. The transcriptional expression of inflammatory cytokines, inflammatory chemokines, and matrix metalloproteinase genes is also regulated, thereby slowing the recruitment of inflammatory cells and the development of inflammation, and increasing keratinocyte mobility. YTCY-EPs can also effectively solve such problems as erythema, papules, cysts, skin lesions, hyperkeratinization, and desquamation caused by C. acnes in rabbit ears. Additionally, the treatment effectively improves the condition of wounds and inflammation. The results of this study prove that YTCY-EPs can be used as a potential anti-acne raw material in cosmetics.

show abstract

Viaminate ameliorates Propionibacterium acnes-induced acne via inhibition of the TLR2/NF-κB and MAPK pathways in rats

Cited by 4 publications

References 36 publications

Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6-Mediated NF-κB and MAPKs Signaling Pathways

Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6-Mediated NF-κB and MAPKs Signaling Pathways

The combination of RL-QN15 and OH-CATH30 to promotes the repair of acne via the TLR2/NF-κB pathway

Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6- Mediated NF-κB and MAPKs Signaling Pathways

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