Vias De Sinalização Celular Envolvidas No Crescimento E Manutenção Do Músculo Estriado Esquelético

Santos, Veridiana Carvalho dos; Sant’Ana, Debora de Mello Gonçalves; Almeida, Fernanda Losi Alves de

doi:10.4025/arqmudi.v23i3.51539

Cited by 1 publication

(1 citation statement)

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“…Morphometric analysis of muscle tissue demonstrated a smaller ratio of nuclei per fiber in EDL muscle of GBH‐F1 animals. An important characteristic of skeletal muscle tissue is its plasticity, which enables the muscle to respond to different metabolic demands (Braun & Gautel, 2011; Buckingham & Rigby, 2014), as occurs in cases of occasional injuries (Santos et al, 2019). However, the reduction of nuclear density in animals exposed to glyphosate impairs this characteristic.…”

Section: Discussionmentioning

confidence: 99%

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Barbosa

Zazula

Oliveira

et al. 2022

The Anatomical Record

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Glyphosate (GBH) is a worldwide consumption pesticide and is used in the formulation of Roundup®, one of the most commercialized herbicides in the world. Maternal exposure to this herbicide can promote changes and adaptations in the offspring; however, the effects on skeletal muscle are poorly understood. In this sense, the present study sought to evaluate the effect of exposure to GBH on the characteristics of the soleus (SOL) and extensor digitorum longus (EDL) muscles. C57BL/6 pregnant female mice were divided into two groups: control (CTL) receiving water and glyphosate (GBH; n = 6) receiving 0.5% glyphosate. Male puppies were designated according to the group to which the mothers belonged, such as CTL‐F1 and GBH‐F1 and then euthanized at 150 days of age. There was a reduction in body weight and nasoanal length of animals exposed to GBH, while there was an increase in EDL weight, reduction in the proportion of fibers and number of nuclei, and an increase in the connective tissue of the SOL. The animals exposed to GBH presented higher values of body characteristics, mainly adiposity gain, while they presented a reduction in neuromuscular junctions (NMJ), and an increase in fibrosis in the SOL muscle, while there was a reduction in the number of nuclei, and an increase in the weight of the EDL muscle. These findings indicate that glyphosate can promote changes in the offspring's body growth, the deposition of adipose panicles and its effects on muscle can lead to changes in the structure and functioning of this tissue.

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Section: Discussionmentioning

confidence: 99%