Active and passive vibration control systems are of paramount importance in many engineering applications. If an external load excites a structure’s resonance and the damping is too low, detrimental events, such as crack initiation, growth and, in the worst case, fatigue failure, can be entailed. Damping systems can be commonly found in applications such as industrial machines, vehicles, buildings, turbomachinery blades, and so forth. Active control systems usually achieve higher damping effectiveness than passive ones, but they need a sensor to detect the working conditions that require damping system activation. Recently, the development of such systems in rotating structures has received considerable interest among designers. As a result, the development of vibration monitoring equipment in rotating structures is also a topic of particular interest. In this respect, a reliable, inexpensive and wireless monitoring system is of utmost importance. Typically, optical systems are used to measure vibrations, but they are expensive and require rather complex processing algorithms. In this paper, a wireless system based on a commercial MEMS accelerometer is developed for rotating blade vibration monitoring. The proposed system measurement accuracy was assessed by means of comparison with a reference wired measurement setup based on a mini integrated circuit piezoelectric (ICP) accelerometer adapted for data acquisition in a rotating frame. Both the accelerometers were mounted on the tip of the blade and, in order to test the structure under different conditions, the first four blade resonances were excited by means of piezoelectric actuators, embedded in a novel experimental setup. The frequency and amplitude of acceleration, simultaneously measured by the reference and MEMS sensors, were compared with each other in order to investigate the viability and accuracy of the proposed wireless monitoring system. The rotor angular speed was varied from 0 to 300 rpm, and the data acquisitions were repeated six times for each considered condition. The outcomes reveal that the wireless measurement system may be successfully used for vibration monitoring in rotating blades.