In order to realistically simulate the flow-induced vibration of submarine oil and gas pipelines, this paper assembles a gas-liquid two-phase flow vibration device, develops a detailed and comprehensive experimental procedure, and sets the flow aperture, flow pressure, flow depth, flow direction, and gas-liquid phase apparent flow rate and other variables. According to the different types of pipelines, the multiphase flow-induced vibration of submarine oil and gas pipelines can be categorized into straight pipe vibration and elbow pipe vibration, and combined with the theoretical knowledge of fluid dynamics and the equations of motion to construct a multiphase flow-induced vibration model of submarine oil and gas pipelines and discuss the vibration mechanism of submarine oil and gas pipelines in two-phase liquid flow. Combined with the corresponding experimental parameters, the vibration phenomenon induced by gas-liquid two-phase flow in submarine oil and gas pipelines is experimentally analyzed. It is analyzed that the first-order intrinsic frequency of the submarine oil and gas pipeline is kept at 23.2 Hz when the value of the Reynolds number of the in-pipe flow ranges from 2.53 × 104 to 1.08 × 107. The first-order intrinsic frequency of the submarine oil and gas pipeline monotonically decreases with the increase of the Reynolds number of the in-pipe flow. In addition, when Ul=0.4m/s, the average standard deviation of the data is only 1.114m/s² with the rise of Ug, indicating that the vibration intensity of the fluid on the subsea oil and gas pipeline increases gradually with the increase of the apparent flow velocity of the liquid phase. By analyzing the multiphase flow problem of oil and gas pipelines, this study is of great significance in improving the efficiency of oil and gas transportation.