Manual wheelchair (MWC) propulsion can expose the user to significant vibration. Human body exposure to certain vibrations can be detrimental to health, and a source of discomfort and fatigue. Therefore, identifying vibration exposure and key parameters influencing vibration transmissibility during MWC propulsion is crucial to protect MWC users from vibration risks. For that purpose, a systematic review using PRISMA recommendations was realizedtosynthesizethe current knowledge regarding vibration transmissibility during MWC propulsion. The 35 retrieved articles were classified into three groups: Vibration content, parameters influencing vibration transmission, and vibration transmission modeling. The review highlighted that MWC users experience vibration in the frequency range detrimental/uncomfortable for human vibration transmission during MWC propulsion depends on many parameters and is still scarcely studied and understood. A modeling and simulation approach would be an interesting way to assist physicians in selecting the best settings for a specific user, but many works (modeling, properties identification, etc.) must be done before being effective for clinical and industrial purposes.