Vibrational and NMR spectra and structures of lithium pyruvate monohydrate

Hanai, Kazuhiko; Kuwae, Akio; Sugawa, Y.; Kunimoto, Ko‐Ki; Maeda, Shiro

doi:10.1016/j.molstruc.2006.10.006

Cited by 8 publications

(22 citation statements)

References 34 publications

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“…The samples (Li-Pyr•H2O and its O-deuterated, 2-C( 18 OH)2, and 13 C-labeled compounds) used in this study are the same as in our previous paper [33]. Li-Pyr•H2O was prepared also by ion exchange of the sodium salt using cation exchange resin (Amberlite IRC-50 (Li + type)).…”

Section: Methodsmentioning

confidence: 99%

“…[40]; judging from the above NMR spectra, these impurities in the samples used are negligibly small in quantity. The 2-13 C( 18 OH)2 analog was prepared from the 2-13 C pyruvate by the method reported previously [33].…”

Section: Methodsmentioning

confidence: 99%

“…Its deuteration purity was checked by NMR spectroscopy. Li-Pyr-d3•D2O was prepared by the same method as in the CH3 compound [33].…”

Section: Methodsmentioning

confidence: 99%

“…In the previous paper [33], we discussed the structures of lithium pyruvate hydrate (Li-Pyr•H2O) and sodium pyruvate (Na-Pyr) by the vibrational and 13 C NMR spectra in the solid state and in aqueous solution and concluded that the solid lithium salt hydrate has the gem-diol structure, namely, is lithium 2,2-dihydroxypropionate, whereas the solid sodium salt takes the ordinary keto form. Zhu et al [34] also reported the results of the solid state 17 O NMR measurements for the pyruvates and gave the same conclusion.…”

Section: Introductionmentioning

confidence: 99%

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Vibrational spectra and normal coordinate analysis of lithium pyruvate monohydrate and its isotopic compounds

et al. 2014

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Its deuteration purity was checked by NMR spectroscopy. Li-Pyr-d3•D2O was prepared by the same method as in the CH3 compound [33].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vibrational spectra and normal coordinate analysis of lithium pyruvate monohydrate and its isotopic compounds

et al. 2014

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“…The investigation was focused mainly within 1750 -1350 cm -1 range because this region is potentially most informative in attempting to assign coordination sites. In sodium pyruvate, strong band at 1709 cm -1 is attributed to the stretching frequency of the ketonic carbonyl group and strong bands at 1654/1631 cm -1 and 1405 cm -1 are attributed to the anti-symmetrical and symmetrical frequencies of carboxylate group, respectively [10,11]. Pyruvates are also twisted in the solid state, but the dihedral angle is not larger than 25°, and sodium interact with both the α-C=O and COO -groups [12].…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characterization and thermal behaviour on solid pyruvates of some bivalent metal ions

Siqueira

Carvalho

Ionashiro³

et al. 2009

Eclet. Quím.

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Solid state M-L compounds, were M stands for bivalent Mn, Fe, Co, Ni, Cu, Zn and L is pyruvate, have been synthesized. Thermogravimetry and derivative thermogravimetry (TG/ DTG), differential scanning calorimetry (DSC), X-Ray powder diffractometry, infrared spectroscopy, elemental analysis, and complexometry were used to characterize and to study the thermal behaviour of these compounds. The results led to information about the composition, dehydration, ligand denticity, and thermal decomposition of the isolated compounds.

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¹H NMR screening of pharmacologically active substances in weight‐loss supplements being sold online

et al. 2012

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Weight-loss or slimming food supplements may be adulterated with synthetic pharmaceuticals, such as anorectic, anxiolytic and antidepressant compounds, especially when sold over the internet. An NMR screening method to detect these pharmacologically active compounds in slimming products is introduced in this study. As a first step, we gathered NMR-related information ( chemical shifts, multiplicity ) both from the scientific literature and own theoretical spectra prediction for 53 substances, which are likely to be illegally present in weight-loss products. The experimental strategy consists of dissolving the samples in a proper solvent ( most commonly ethanol ) and manually comparing each observed chemical shift with table values and thus identifying possible adulteration. A compound is considered to be identified if all the compound's resonances were present with correct multiplicity ( finally confirmed by J-resolved 2D spectra ). The method has been introduced in routine practise in our institute and we have already detected sibutramine, caffeine and L-carnitine in slimming products. Furthermore, quantification can be conducted by simple integration of a target resonance in comparison with the internal reference standard ( e. g., TSP ), or by using standard solutions ( when available ). We believe that NMR is ideally suited to controlling dietary supplements as it provides qualitative and at least semi-quantitative information more rapidly ( measurement time of about 20 min ) than with any other currently available spectroscopic or chromatographic method. Future research regarding the automation of spectral processing and inclusion of non-targeted analysis is necessary.

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Vibrational and NMR spectra and structures of lithium pyruvate monohydrate

Cited by 8 publications

References 34 publications

Vibrational spectra and normal coordinate analysis of lithium pyruvate monohydrate and its isotopic compounds

Vibrational spectra and normal coordinate analysis of lithium pyruvate monohydrate and its isotopic compounds

Synthesis, characterization and thermal behaviour on solid pyruvates of some bivalent metal ions

¹H NMR screening of pharmacologically active substances in weight‐loss supplements being sold online

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Vibrational and NMR spectra and structures of lithium pyruvate monohydrate

Cited by 8 publications

References 34 publications

Vibrational spectra and normal coordinate analysis of lithium pyruvate monohydrate and its isotopic compounds

Vibrational spectra and normal coordinate analysis of lithium pyruvate monohydrate and its isotopic compounds

Synthesis, characterization and thermal behaviour on solid pyruvates of some bivalent metal ions

1H NMR screening of pharmacologically active substances in weight‐loss supplements being sold online

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¹H NMR screening of pharmacologically active substances in weight‐loss supplements being sold online