Vibrational and thermal analyses of multicomponent crystal forms of the anti-HIV drugs lamivudine and zalcitabine

Martins, Felipe Terra; Guimarães, Fernando; Honorato, Sara B.; Ayala, A. P.; Ellena, Javier

doi:10.1016/j.jpba.2015.03.004

Cited by 9 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the sharp endothermic peak at a temperature of 171.40°C is the new melting point of the multi-component crystal phase. The results of the DSC thermal analysis supported the PXRD analysis, that between trimethoprim and citric acid, a new multi-component crystal phase was formed [21].…”

Section: Figure 2a Displays a Thermogram Of Trimethoprim Which Shows ...supporting

confidence: 64%

“…The presence of solid-state interactions between components in a crystalline multicomponent system is indicated by the presence of a new or a shifting transmittance peak. The presence of hydrogen bonds formed between the two solid substances is indicated by a shift in the wavenumber [21], [22]. , the C=N group from 1636.70 cm −1 to 1589.37 cm −1 and the C=H group from 1464.00 to 1452.42 cm −1 .…”

Section: Figure 2a Displays a Thermogram Of Trimethoprim Which Shows ...mentioning

confidence: 99%

See 1 more Smart Citation

Multicomponent Crystal of Trimethoprim and Citric Acid: Solid State Characterization and Dissolution Rate Studies

Umar

Farnandi

Salsabila

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Trimethoprim is a broad spectrum antimicrobial agent with low solubility in water which causes low bioavailability in systemic circulation. AIM: The purpose of this study was to prepare multicomponent crystals of trimethoprim and citric acid to increase the solubility and dissolution rate of trimethoprim. MATERIALS AND METHODS: Multicomponent crystals were prepared by solvent evaporation method. Characterizations of multicomponent crystalline solid phase properties were carried out by powder X-ray diffraction (PXRD) analysis, differential scanning calorimetry (DSC), FT-IR spectroscopy, scanning electron microscopy (SEM). Solubility and dissolution rate tests were carried out in aqueous medium. RESULTS: The PXRD characterization results showed a new X-ray diffraction pattern in the multicomponent crystal phase. DSC analysis showed the formation of a new endothermic peak. This indicates the formation of a multicomponent crystal phase between trimethoprim and citric acid. The results of the SEM analysis indicate the formation of a new crystal habit. Solubility of multi-component crystal phase of trimethoprim increased 7 times compared to intact trimethoprim. The dissolution of trimethoprim and multicomponent crystals in 0.1 N HCl medium at 60 minutes was 56.36% and 95.57% and CO2-free distilled water medium was 43.03% and 88.26%, respectively. CONCLUSIONS: From the results of the study, it can be concluded that the multicomponent phase of trimethoprim crystals with citric acid successfully increase the solubility and dissolution rate of trimethoprim significantly.

show abstract

Section: Figure 2a Displays a Thermogram Of Trimethoprim Which Shows ...supporting

confidence: 64%

Section: Figure 2a Displays a Thermogram Of Trimethoprim Which Shows ...mentioning

confidence: 99%

Multicomponent Crystal of Trimethoprim and Citric Acid: Solid State Characterization and Dissolution Rate Studies

Umar

Farnandi

Salsabila

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…Thermal analysis has been used to determine the physical and chemical properties of various types of materials [1][2][3][4][5][6]. Scientific and technological achievements together with demands based on industrial requirement have permitted the development of various types of materials that can withstand at much higher temperatures and more corrosive environments.…”

Section: Introductionmentioning

confidence: 99%

Thermal analysis of some novel pyrimidine derivatives

Baluja

Bhalodia

Gajera

et al. 2019

Rev. Colomb. Cienc. Quím. Farm.

View full text Add to dashboard Cite

Some new pyrimidine derivatives have been synthesized and their decomposition characteristics have been studied by thermogravimetric and differential scanning calorimetric analysis. The thermal stability and some kinetics parameters of decomposition were evaluated from thermograms. It is observed that depending upon the structure, substitutions, thermal stability and decomposition kinetics varies in different compounds.

show abstract

“…A co-crystal is a crystalline solid formed by two or more molecular and/or ionic components in the same crystal lattice, while a molecular salt is authored by proton transfer from a donor molecule (acid) to an acceptor molecule (base) as a function of the ionic character of the bond. [11][12][13] Our research group has been working for several years on the structural analysis of a variety of molecular compounds, 14,15 pharmaceutical co-crystals [16][17][18] and MOFs [19][20][21][22][23] exploring the structure-property correlations in the solid state. In the present work, we report an uncommon case of a molecular complex with an order-disorder conformational transition.…”

Section: Introductionmentioning

confidence: 99%

Order–disorder phase transition induced by proton transfer in a co-crystal of 2,4-dichlorobenzoic acid and trimethylamine N-oxide

et al. 2017

View full text Add to dashboard Cite

This version is available at https://strathprints.strath.ac.uk/61034/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output. Journal Name ARTICLEThis journal is © The Royal Society of Chemistry 20xx J. Name., 2013, 00, 1-3 | 1 The crystalline binary adduct between the trimethylamine N-oxide (TMANO) and 2,4-dichlorobenzoic acid (2,4-DCBA) molecules was obtained by slow evaporation from acetonitrile. The obtained molecular complex is formed by a racemic mixture of molecular complexes crystallizing in the orthorhombic space group Pbca. An exhaustive analysis of the temperature dependence of the cell parameters and the behavior of the acidic hydrogen position and carboxilate group were studied by single crystal and powder X-ray diffraction, FT-IR spectroscopy and theoretical calculations. The molecular system was thermally characterized, subsequently demonstrating a order-disorder transition. Finally, the intermolecular interactions were analyzed via Hirshfeld surface analysis.

show abstract

Vibrational and thermal analyses of multicomponent crystal forms of the anti-HIV drugs lamivudine and zalcitabine

Cited by 9 publications

References 24 publications

Multicomponent Crystal of Trimethoprim and Citric Acid: Solid State Characterization and Dissolution Rate Studies

Multicomponent Crystal of Trimethoprim and Citric Acid: Solid State Characterization and Dissolution Rate Studies

Thermal analysis of some novel pyrimidine derivatives

Order–disorder phase transition induced by proton transfer in a co-crystal of 2,4-dichlorobenzoic acid and trimethylamine N-oxide

Contact Info

Product

Resources

About