Vibrational spectra of the organometallic estrogen‐receptor marker [3‐O‐(3‐hydroxypropyl)‐17β‐estradiol]‐α‐tricarbonylchromium(0) and related compounds

Abstract

The IR, micro-Raman and Fourier transform (FT) Raman spectra of 3-O-(3-hydroxypropyl)-l7~~tradiol and the two (a and 8) diastereomers, produced by coordination of a Cr(CO), moiety to the arene A ring of the steroid, are presented. The three compounds exhibit spectra typical of arene hormonal steroids and the a-and /l-diastereomers can be readily distinguished from one another, especially by their FT-Raman spectra in the CO stretching region which, unlike the corresponding micro-Raman data, are not significantly masked by the presence of strong fluorescence backgrounds. This distinction is important since the adiastereomer is a useful IR estrogen-receptor marker, whereas the b-diastereomer is not.