To investigate the gearbox radiation noise properties under various rotational speeds, a noise prediction method based on impedance model and noise transfer function (NTF) is proposed. One only needs to extract the NTF of the housing once rapid gearbox noise prediction under different working conditions is realized. Taking a flexible supported gearbox as a research object, the external excitation of the housing (the bearing excitation load and isolator excitation load) is calculated through a gear-housing-foundation-coupled impedance model, and the noise transfer function is simulated through the vibroacoustic-coupled boundary element model; then the radiation noise is obtained. Based on this model, the noise transfer analysis of the housing is carried out, different excitation components and NTF components are compared, and the contributions of different excitation components to noise are compared. Results show that the radiation noise of gearbox is mainly excited by the high-speed bearing, while the low-speed bearing and isolator have little influence on noise. At low speed, vertical force, axial force, and moment excitation of bearings all contribute to the radiation noise while at high speed, the gearbox radiation noise is mainly generated by vertical excitation force of bearings.