Vibrio cholerae Flagellar Synthesis and Virulence

Anastasia, R.; Karl, Ewald

doi:10.5772/38457

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Motility and Virulence1

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2019

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“…There is evidence for inverse regulation of motility and virulence genes in V. cholerae (Gardel and Mekalanos, 1996; Syed et al, 2009; Syed and Klose, 2011; Rugel and Klose, 2012). The V. cholerae ToxR regulon responds to environmental stimuli to regulate ToxT expression, which then activates transcription of the virulence-associated cholera toxin ( ctx ), toxin co-regulated pilus ( tcp ), and accessory colonization factor ( acf ) genes (Childers and Klose, 2007).…”

Section: Motility and Virulencementioning

confidence: 99%

Vibrio Flagellar Synthesis

Echazarreta

Klose

2019

Front. Cell. Infect. Microbiol.

106

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Vibrio spp. are highly motile Gram-negative bacteria, ubiquitously found in aquatic environments. Some Vibrio s are responsible for disease and morbidity of marine invertebrates and humans, while others are studied for their symbiotic interactions. Vibrio spp. are motile due to synthesis of flagella that rotate and propel the bacteria. Many Vibrio spp. synthesize monotrichous polar flagella (e.g., V. cholerae, V. alginolyticus ); however, some synthesize peritrichous or lophotrichous flagella. Flagellar-mediated motility is intimately connected to biological and cellular processes such as chemotaxis, biofilm formation, colonization, and virulence of Vibrio spp. This review focuses on the polar flagellum and its regulation in regard to Vibrio virulence and environmental persistence.

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