Vibrio vulnificus, an Underestimated Zoonotic Pathogen

Amaro, Carmen; Carmona-Salido, Héctor

doi:10.1007/978-3-031-22997-8_9

Cited by 8 publications

(7 citation statements)

References 79 publications

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“…It is worth noting that biotype 2 strains function as a zoonotic agent. 5 6 The biotype 2 strains are classified into serotypes A and E. 7,8…”

Section: Retrosynthetic Analysismentioning

confidence: 99%

“…It is worth noting that biotype 2 strains function as a zoonotic agent. 5,6 The biotype 2 strains are classified into serotypes A and E. 7,8 Typically, V. vulnificus infections are treated with antibiotics, while management of the infection site, such as surgical cleaning of damaged tissues, is commonly necessary. 9 In some cases, amputation of affected limbs is required.…”

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confidence: 99%

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Chemical Synthesis of a Disaccharide from Vibrio vulnificus Biotype 2 Serovar A O-Antigen Containing a Rare l-GalpNAmA

Qin,

Zhu,

et al. 2024

Synthesis

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Vibrio vulnificus can cause severe infections internally and externally. The mortality rate of V. vulnificus-associated gangrene and septicemia has increased due to antibiotic resistance and the absence of human vaccine. Bacterial carbohydrates have been widely used in the development of bacterial vaccines. Here, a rare L-GalpNAmA-containing disaccharide exists in V. vulnificus biotype 2 serovar A O-antigen was synthesized from D-glucose and L-galactose. An investigation on the influence of different linkers on the disaccharide synthetic efficiency indicated that the amine linker has more practicality. Two α-glycosidic linkages were constructed with good stereoselectivity by using nonparticipating C2 azido group and solvent effect. An orthogonal protection strategy allowed introductions of carboxyl and acetamidino (Am) groups at the disaccharide stage. The synthesis of the amine-linked disaccharide will provide a basis for the preparation of the trisaccharide repeating unit and longer fragments of V. vulnificus biotype 2 serovar A O-antigen, as well as other complex glycans.

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“…It is worth noting that biotype 2 strains function as a zoonotic agent. 5 6 The biotype 2 strains are classified into serotypes A and E. 7,8…”

Section: Retrosynthetic Analysismentioning

confidence: 99%

mentioning

confidence: 99%

Chemical Synthesis of a Disaccharide from Vibrio vulnificus Biotype 2 Serovar A O-Antigen Containing a Rare l-GalpNAmA

Qin,

Zhu,

et al. 2024

Synthesis

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“…For example, Sánchez-Busó et al ( 2015 ) estimated that ~98% of the SNPs incorporated in an outbreak-related lineage of Legionella pneumophila originated from recombination with other strains of the same species. In the case of V. vulnificus , we know that the acquisition of the virulence plasmid has been very important for the emergence of new lineages linked to fish farms (Amaro and Carmona-Salido, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Vibrio vulnificus mutation rate: an in vitro approach

et al. 2023

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Vibrio vulnificus is a multi-host pathogenic species currently subdivided into five phylogenetic lineages (L) plus one pathovar with the ability to infect fish due to a transmissible virulence plasmid. This plasmid (or a fragment of it) has been transmitted between lineages within the species, contributing to the evolution of V. vulnificus. This study aimed to provide an experimental approximation to the V. vulnificus mutation rate by determining spontaneous mutation rates from bacterial cultures of representants of the different lineages by whole-genome sequencing. To this purpose, synonymous SNP differences, i.e., spontaneous mutation not subjected to the evolutive forces, between initial and final culture after serial growth were evaluated and used for mutation rate calculation.

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“…It is a lethal zoonotic disease and its virulence is due to horizontal gene transfer in V. vulnificus and subsequently from aquaculture farms to human health. 3 Globally the pooled prevalence of V. vulnificus in fishes was 5.29%. 4 In 2018, vibriosis caused by V. vulnificus was 17.2 times more severe than infections with other species of vibrio with higher prevalence in the age group ⩾65 years.…”

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confidence: 97%

“…1 The halophilic (salt-requiring) gram-negative bacteria namely V. vulnificus, exist naturally in seawater with increased infection occurrence and severity in warm summers (water temperature exceeds 150C) due to climatic change effects. 2,3 Additionally, the increased salinity of seawater has predisposed to higher prevalence rates of V. vulnificus (salinity range between 21% and 33%). 2 The reservoir of infection is sea animals and it is associated with eating sea foods, especially raw or uncooked oysters.…”

mentioning

confidence: 99%

The Rising Tide of a Deadly Bacteria: How Warming Waters are Fueling the Spread of Vibrio Vulnificus

Choudhary,

Satapathy,

Mital

et al. 2023

Microbiol�Insights

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Warming waters have been linked to the increase in infections with the rare flesh-eating bacterium Vibrio vulnificus, which is now moving along the east coast of the United States. This bacterium can cause life-threatening wound infections, with many people requiring intensive care or limb amputations, and about 1 in 5 people with this infection dying, sometimes within a day or 2 of becoming ill. This bacterium can lead to necrotizing fasciitis, a severe infection in which the flesh around an open wound dies.Recently in July 2023, the North Carolina state reported the deaths of 3 residents after their open wounds came into contact with brackish water near the coast. The North Carolina Department of Health and Human Services (NCDHHS) is issuing a warning about this alarming V. vulnificus infection. Vibriosis is rare in this state and cases are mostly reported from June-September. NCDHHS also confirms that one individual also had consumed personally caught seafood that was not shared. Since 2019, 47 cases have been reported in North Carolina with a 17% case fatality rate. 1 The halophilic (salt-requiring) gram-negative bacteria namely V. vulnificus, exist naturally in seawater with increased infection occurrence and severity in warm summers (water temperature exceeds 150C) due to climatic change effects. 2,3 Additionally, the increased salinity of seawater has predisposed to higher prevalence rates of V. vulnificus (salinity range between 21% and 33%). 2 The reservoir of infection is sea animals and it is associated with eating sea foods, especially raw or uncooked oysters. It is a lethal zoonotic disease and its virulence is due to horizontal gene transfer in V. vulnificus and subsequently from aquaculture farms to human health. 3 Globally the pooled prevalence of V. vulnificus in fishes was 5.29%. 4 In 2018, vibriosis caused by V. vulnificus was 17.2 times more

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Vibrio vulnificus, an Underestimated Zoonotic Pathogen

Cited by 8 publications

References 79 publications

Chemical Synthesis of a Disaccharide from Vibrio vulnificus Biotype 2 Serovar A O-Antigen Containing a Rare l-GalpNAmA

Chemical Synthesis of a Disaccharide from Vibrio vulnificus Biotype 2 Serovar A O-Antigen Containing a Rare l-GalpNAmA

Vibrio vulnificus mutation rate: an in vitro approach

The Rising Tide of a Deadly Bacteria: How Warming Waters are Fueling the Spread of Vibrio Vulnificus

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