A new vibro-acoustic method is presented to analyze the sound radiation behavior of orthotropic panel-form sound radiators using strip-type exciters to exert line loads to the panels for sound radiation. The simple first-order shear deformation theory together with the Ritz method is used to formulate the proposed method that makes the vibro-acoustic analysis of elastically restrained stiffened orthotropic plates more computationally efficient than the methods formulated on the basis of the other shear deformation theories. An elastically restrained orthotropic plate consisting of two parallel strip-type exciters was tested to measure the experimental sound pressure level curve for validating the effectiveness and accuracy of the proposed method. The resonance characteristics (natural frequency and mode shape) detrimental to sound radiation are identified in the vibro-acoustic analysis of the orthotropic plate. For any orthotropic sound radiation plate, based on the detrimental mode shapes, a practical procedure is presented to design the line load locations on the plate to suppress the major sound pressure level dips for enhancing the smoothness of the plate sound pressure level curve. For illustration, the sound radiation enhancement of orthotropic plates with different fiber orientations for aspect ratios equal to 3, 2, and 1 subjected to one or two line loads is conducted using the proposed procedure. The results for the cases with two line loads perpendicular to the fiber direction and located at the nodal lines of the major detrimental mode shape may find applications in designing orthotropic panel-form speakers with relatively smooth sound pressure level curves.