C oronary artery disease is associated with more death and disabilities than any other disease in industrialized nations. Coronary artery bypass graft surgery (CABG) is one of the most effective methods of treating symptomatic coronary artery disease and is performed in approximately 10,000 patients annually in Ontario.The majority of cardiac operations require the establishment of cardiopulmonary bypass and cardioplegic arrest. However, cardiopulmonary bypass is a well-recognized factor for generating a whole-body inflammatory response, which can contribute to postoperative morbidity including renal, pulmonary, neurological and bleeding complications (1,2). Benetti et al (3) and Buffolo et al (4) reintroduced beating heart surgery almost 20 years ago as a strategy to prevent complications in high-risk patients. Since that time, off-pump coronary artery bypass (OPCAB) surgery has gained increasing popularity and is challenging conventional on-pump coronary artery bypass (CCAB) as the standard of therapy for multivessel disease in many cardiac centres (2).The benefits of OPCAB remain controversial, despite the publication of numerous studies reporting equivalent or improved hospital outcomes and significantly shorter lengths of hospital stay. Ascione and Angelini (5) discussed the dilemma faced by many cardiac surgeons who perform CABG. On one hand, the literature is replete with studies that emphasize the potential for reducing postoperative morbidity and length of stay with OPCAB surgery (6-24); on the other hand, there is continued concern regarding intraoperative myocardial ischemia, inadequate revascularization and the need for early revascularization (5,8,23,(25)(26)(27)(28)(29).Therefore, the purpose of the present study was to evaluate midterm outcomes of OPCAB versus conventional CCAB in two wellmatched cohorts.
CLINICAL STUDIES©2008 Pulsus Group Inc. All rights reserved OBJECTIVE: To evaluate survival and readmissions to hospital for cardiac events or coronary revascularization (REVASC) in patients having off-pump (OPCAB) versus conventional on-pump (CCAB) coronary artery bypass graft surgery (CABG). METHODS: Of 11,368 consecutive patients undergoing isolated CABG between 1996 and 2002, 514 had OPCAB surgery. Using propensity scores, 503 CCAB patients were randomly matched to 503 OPCAB patients. RESULTS: There were no clinical or statistical differences between the two groups for any prognostic variable. However, OPCAB patients received significantly fewer distal anastomoses than the CCAB group (2.6±1.0 versus 3.1±1.0; P<0.001). There was no difference in operative mortality (OPCAB 1.0%, CCAB 1.4%; P=0.6), but the OPCAB group had significantly fewer operative strokes (0.2% versus 1.8%; P=0.01). Follow-up was 99.7% complete at 2.2±1.2 years (range 0 to 6 years). Twice as many OPCAB patients (n=24) required REVASC compared with the CCAB (n=11) group. The following five-year actuarial outcomes are presented for CCAB and OPCAB, respectively: survival: 77±6%, 76±8%, P=0.8; freedom from REVASC: 95±3%, 92±2%, ...