Video Camera Method for Simultaneous Measurement of Blood Flow Velocity and Pial Vessel Diameter

Gotoh, Fumio; Muramatsu, Fumio; Fukuuchi, Yasuo; Okayasu, Hiroyuki; Tanaka, Kortaro; Suzuki, Noriyuki; Kobari, Masahiro

doi:10.1038/jcbfm.1982.48

Cited by 24 publications

(10 citation statements)

References 19 publications

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“…The latter limitation is overcome by concurrent measurement of blood flow velocity. Blood flow velocity has been measured simultaneously with diameter using a miniaturized pulsed-doppler probe (Busi]a et al 1981 ) or timed passage of a saline pulse (Gotoh et al 1982). Calculated blood flow using the former method has been compared with measurements with microspheres and the agreement has been excellent (Busi]a et al 1981).…”

Section: Methods To Characterize Cerebrovascular Responsesmentioning

confidence: 99%

Factors involved in the physiological regulation of the cerebral circulation

Busija

Heistad

1984

Reviews of Physiology, Biochemistry and Pharmacology

223

136

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Section: Methods To Characterize Cerebrovascular Responsesmentioning

confidence: 99%

Factors involved in the physiological regulation of the cerebral circulation

Busija

Heistad

1984

Reviews of Physiology, Biochemistry and Pharmacology

223

136

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“…1996). Vasomotion has been well characterized in some cerebral vessels of anaesthetized cats (Auer & Gallhofer 1981, Gotoh et al. 1982).…”

Section: Physiology Of Vasomotionmentioning

confidence: 99%

“…In cerebral circulation, vasomotion has been reported both in isolated human and rat cerebral vessels (Fujii et al 1990, Gokina et al 1996. Vasomotion has been well characterized in some cerebral vessels of anaesthetized cats (Auer & Gallhofer 1981, Gotoh et al 1982. But later it has been shown that active vasomotion was observed in rabbit cerebral microcirculation under wakeful conditions while it was depressed by anaesthesia (Hundley et al, 1988).…”

Section: Physiology Of Vasomotionmentioning

confidence: 99%

Informational dynamics of vasomotion in microvascular networks: a review

Pradhan

Chakravarthy

2010

Acta Physiologica

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Vasomotion refers to spontaneous oscillation of small vessels observed in many microvascular beds. It is an intrinsic phenomenon unrelated to cardiac rhythm or neural and hormonal regulation. Vasomotion is found to be particularly prominent under conditions of metabolic stress. In spite of a significant existent literature on vasomotion, its physiological and pathophysiological roles are not clear. It is thought that modulation of vasomotion by vasoactive substances released by metabolizing tissue plays a role in ensuring optimal delivery of nutrients to the tissue. Vasomotion rhythms exhibit a great variety of temporal patterns from regular oscillations to chaos. The nature of vasomotion rhythm is believed to be significant to its function, with chaotic vasomotion offering several physiological advantages over regular, periodic vasomotion. In this article, we emphasize that vasomotion is best understood as a network phenomenon. When there is a local metabolic demand in tissue, an ideal vascular response should extend beyond local microvasculature, with coordinated changes over multiple vascular segments. Mechanisms of information transfer over a vessel network have been discussed in the literature. The microvascular system may be regarded as a network of dynamic elements, interacting, either over the vascular anatomical network via gap junctions, or physiologically by exchange of vasoactive substances. Drawing analogies with spatiotemporal patterns in neuronal networks of central nervous system, we ask if properties like synchronization/desynchronization of vasomotors have special significance to microcirculation. Thus the contemporary literature throws up a novel view of microcirculation as a network that exhibits complex, spatiotemporal and informational dynamics.

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“…The technical details of the system have been described elsewhere (Okayasu et al. 1979;Gotoh et al. 1982).…”

Section: Methodsmentioning

confidence: 99%

Comparison between Pial and Intraparenchymal Vascular Responses to Cervical Sympathetic Stimulation in Cats. Part 1. Under Normal Resting Conditions

Gotoh

Fukuuchi

Amano

et al. 1986

J Cereb Blood Flow Metab

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Summary:To investigate the role of sympathetic regula tion in both resistance and capacitance vessels in cerebral circulation, the responses of pial and intraparenchymal vessels to sympathetic nerve stimulation were simulta neously examined in 14 cats by means of a newly devel oped video camera photoelectric system. The system consisted of a video camera system for measurement of pial vascular diameters and a photoelectric apparatus for estimating regional cerebral blood volume in the intrapa renchymal vessels. The ipsilateral superior cervical gan glion was electrically stimulated for 5 min. Initially. both the pial and intraparenchymal vessels constricted. TheIt is well documented that sympathetic nerves derived from the superior cervical ganglion con strict cerebral vessels down to the pial arterioles and venules (Auer et aI. , 1982) and exert a protec tive effect against breakthrough of autoregulation of CBF during acute hypertension (Bill and Linder, 1976). However, the role of the sympathetic nerves in the regulation of the resting CBF is still disputed Purves, 1978). This controversy seems to depend partly on the method ological limitations of measuring CBF and on the homeostatic mechanism of cerebral circulation. Harper et al. (1972) hypothesized that under most circumstances, sympathetic constriction of the ex traparenchymal and pial vessels might be com pen- 342large pial arteries (173 ± 25 f.Lm, mean ± SEM) remained constricted throughout the stimulation. whereas the in traparenchymal vessels began to dilate after the initial constriction and exceeded the control level at 175 ± 25 s despite continued stimulation. In conclusion. such sym pathetic nerve stimulation is considered to exert a con strictive effect on the intraparenchymal as well as the pial vessels at the early stage. The compensatory dilation of the intraparenchymal vessels was delayed 3 min after ini tiation of the stimulation. Key Words: Cerebral blood volume-Escape phenomenon-Pial vessel-Sympa thetic stimulation. sated for by a metabolic dilation of the intraparen chymal vessels and that CBF might be kept con stant. Recently, we developed a video camera photoelectric system that permits simultaneous and continuous measurement of pial vascular diameter and changes in regional cerebral blood volume (CBV). In the present study, to test Harper et al. 's hypothesis, we compared the responses of pial and intraparenchymal vessels to superior cervical gan glion stimulation by using this new method. MATERIALS AND METHODSExperiments were performed on 14 cats weighing from 2.3 to 3.4 kg, anesthetized by intraperitoneal injection of a-chloralose (50 mg/kg) and urethane (5 00 mg/kg). The bilateral femoral arteries and one femoral vein were can nulated for monitoring arterial blood pressure (BP). ana lyzing blood gases. and injection of drugs. The animals were subjected to tracheostomy and were ventilated with a respirator (Harvard 662) after immobilization with al curonium chloride (2 mg i.v.). The animal's head was fixed in a stereotactic head ho...

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Video Camera Method for Simultaneous Measurement of Blood Flow Velocity and Pial Vessel Diameter

Cited by 24 publications

References 19 publications

Factors involved in the physiological regulation of the cerebral circulation

Factors involved in the physiological regulation of the cerebral circulation

Informational dynamics of vasomotion in microvascular networks: a review

Comparison between Pial and Intraparenchymal Vascular Responses to Cervical Sympathetic Stimulation in Cats. Part 1. Under Normal Resting Conditions

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