“…However not all reported better test characteristics at 6 h than earlier with Shany et al (2006) reporting the sensitivity of burst suppression at 3 h to be 83% and at 6 h to be 75%. Hallberg et al, 2010;Thoresen et al, 2010;Ancora et al, 2011;Hamelin et al, 2011;Nash et al, 2011;Gucuyener et al, 2012;Csek} o et al, 2013) used hypothermia in their HIE management. Letter 'b' and 'a' after the year of publication in the forest plots indicate the measure before and after cooling respectively of the same study.…”
Section: Issues Relating To the Definitions Of Abnormal Patternsmentioning
“…However not all reported better test characteristics at 6 h than earlier with Shany et al (2006) reporting the sensitivity of burst suppression at 3 h to be 83% and at 6 h to be 75%. Hallberg et al, 2010;Thoresen et al, 2010;Ancora et al, 2011;Hamelin et al, 2011;Nash et al, 2011;Gucuyener et al, 2012;Csek} o et al, 2013) used hypothermia in their HIE management. Letter 'b' and 'a' after the year of publication in the forest plots indicate the measure before and after cooling respectively of the same study.…”
Section: Issues Relating To the Definitions Of Abnormal Patternsmentioning
“…However, we consider that the maximum grade was a better predictor than minimum grade because the AUC and sensitivity were slightly greater for the maximum grade than for the minimum grade. Many reports have demonstrated the high predictive value of cEEG [6][7][8][9]. In most of these studies, cEEG recording commenced more than 10 h after birth, except in the study by Murray et al [7], in which cEEG recording was initiated a mean of 5 h after birth.…”
Section: Maximum Eeg Depression Gradementioning
confidence: 99%
“…Conventional electroencephalogram (cEEG) is a highly reliable predictor of outcome in term infants with HIE [6][7][8][9]. However, the previous cEEG classification criteria require a recording time of 45-120 min because assessments of sleep-wake cycles or cEEG patterns during all sleep stages are needed for most of these criteria.…”
“…EEG appears not to be significantly affected by HT [113,114] and so it is reasonable to include studies with babies treated with HT as we have done for [47,[51][52][53][54][55].…”
Section: Validity Of Results In Newborns Treated With Hypothermiamentioning
Neonatal Hypoxic Ischaemic Encephalopathy (HIE) is a major cause of morbidity and mortality in newborns throughout the world with an incidence of 1-8/1000 newborns in developed countries and up to 26/1000 newborns in developing countries. It causes one million neonatal deaths globally per year. Electroencephalography (EEG) is a useful method for assessment of brain activity in newborns with HIE. EEG performs well in the early diagnosis and classification of HIE severity and in predicting neurodevelopmental outcome. A normal EEG is highly predictive of a normal outcome and various abnormal EEG features are associated with neurological abnormalities or death.A systematic review and meta-analysis of the literature was undertaken to determine which specific background features of the EEG best predict outcome (Aim 1). Automatic detection and classification
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