Objective-To report a technique for minimally invasive occlusion of patent ductus arteriosus (PDA) and outcome in 5 dogs. Study Design-Clinical cases. Animals-Five, 4-6-month-old, dogs with PDA. Materials and Methods-Titanium ligating clips were used for PDA closure in all dogs. Three dogs had video-enhanced mini-thoracotomy PDA occlusion. Two other dogs had thoracoscopic PDA occlusion using a custom-designed thoracoscopy clip applicator. Results-Thoracoscopic PDA occlusion was successful in both dogs in which it was attempted. Complete PDA closure was achieved in 4 dogs. Three months after surgery, the largest dog had residual ductal flow that hemodynamically was insignificant. Conclusions-Although technically demanding, minimally invasive PDA occlusion is a safe and reliable technique in dogs. Preoperative measurement of the diameter of the PDA is crucial to determine if complete closure with metal clips can be achieved. Clinical Relevance-Minimally invasive PDA occlusion should be considered as an alternative to occlusion via conventional thoracotomy. r