Vigabatrin (Sabril)

Kurland, Alan H.; Browne, Thomas R.

doi:10.1097/00002826-199412000-00003

Cited by 7 publications

(4 citation statements)

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“…202 In addition, (aminooxy)acetic acid (48, Fig. 17) is a potent anticonvulsant; it is thought to act, at least in part, by inhibition of GABA-T, thus, raising brain levels of GABA.…”

Section: Gaba-transaminase Inhibitionmentioning

confidence: 99%

Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents

Lin¹,

Kadaba²

1997

Med. Res. Rev.

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“…202 In addition, (aminooxy)acetic acid (48, Fig. 17) is a potent anticonvulsant; it is thought to act, at least in part, by inhibition of GABA-T, thus, raising brain levels of GABA.…”

Section: Gaba-transaminase Inhibitionmentioning

confidence: 99%

Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents

Lin¹,

Kadaba²

1997

Med. Res. Rev.

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“…Vigabatrin, a well-tolerated specific GABA transaminase inhibitor, is used as an AED [105] and to treat startle disease in neonates [106]. In a series of five chronic PTSD patients with prominent hypervigilance/startle, vigabatrin augmentation at low doses (250-500 mg/d) resulted in rapid improvement of their exaggerated startle responses and had a general calming effect [107].…”

Section: Other Aedsmentioning

confidence: 99%

Antiepileptic drugs for the treatment of post-traumatic stress disorder

Berlin

2007

Curr Psychiatry Rep

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Post-traumatic stress disorder (PTSD) is a disruptive, chronic, and relatively common disorder that is often difficult to treat. Many patients with PTSD are unresponsive, have only moderate or marginal responses, or have troubling side effects to first-line serotonin reuptake inhibitor treatment. Studies suggest that antiepileptic drugs (AEDs) may be an effective treatment alternative or adjunctive treatment for the symptoms of PTSD. Recent results from case reports and open and controlled studies on the efficacy and tolerability of AEDs in PTSD are reviewed here, and their methodological limitations are discussed when relevant. AEDs shown to be effective in double-blind, placebo-controlled trials of PTSD include lamotrigine, topiramate, and tiagabine. Other AEDs that appear promising in open-label trials of PTSD include carbamazepine, valproate, gabapentin, vigabatrin, phenytoin, and levetiracetam. Stress-activated limbic kindling may be involved in the pathogenesis of PTSD. The possibility that AEDs may be effective in the treatment of PTSD due to their antikindling effect is discussed, and suggestions for future research are made.

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“…An interesting recent report described the effectiveness of a different anticonvulsant, vigabatrin, a specific gamma aminobutyric acid (GABA) transaminase inhibitor that is an effective anticonvulsant which has been used to treat startle disease (hyperekplexia) of neonates 47 . 48 As fear‐potentiated startle has been proposed as a psychobiologic mechanism for PTSD, MacLeod prescribed vigabatrin to five PTSD patients whose persistent startle and hypervigilance had not responded to other medications 4 .…”

Section: Anticonvulsantsmentioning

confidence: 99%

Pharmacotherapy for posttraumatic stress disorder: A status report

Friedman

1998

Psychiatry Clin Neurosci

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Pharmacotherapy for posttraumatic stress disorder (PTSD) appears to be a promising approach because many neurobiological systems appear to be altered in PTSD patients. This review encompasses the current published literature on clinical trials with antiadrenergic agents (propranolol, clonidine, guanfacine), selective serotonin reuptake inhibitors (SSRI), other serotonergic agents, monoamine oxidase inhibitors (MAOI), tricyclic antidepressants (TCA), benzodiazepines, anticonvulsants, narcotic antagonists and antipsychotic agents. It is suggested that although more randomized clinical trials are needed with the drugs cited in the present review, that an important future direction would be with drugs that directly modify the complex psychobiology of the human stress response, in general, and PTSD‐related abnormalities, in particular.

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Vigabatrin (Sabril)

Cited by 7 publications

References 0 publications

Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents

Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents

Antiepileptic drugs for the treatment of post-traumatic stress disorder

Pharmacotherapy for posttraumatic stress disorder: A status report

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