Vigna radiata (L.) R. Wilczek Extract Inhibits Influenza A Virus by Targeting Viral Attachment, Penetration, Assembly, and Release

Lo, Chieh-Wen; Pi, Chia-Chen; Chen, Youting; Chen, Hui-Wen

doi:10.3389/fphar.2020.584973

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…It had been verified that isovitexin inhibits viral replication on mammalian H1N1, avian influenza H5N1, and avian H6N1. It also acts against the cytopathic effect induced by influenza virus infection [ 37 , 38 ]. One study has suggested that procyanidin exerted inhibitory activity on influenza virus by inhibiting the formation of the Atg5-Atg12/Atg16 Heterotrimer and Beclin1/bcl2 Heterodimer [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis

Wang

Peng

et al. 2021

Mol Divers

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Graphic abstract Traditional Chinese medicine (TCM) has exerted positive effects in controlling the COVID-19 pandemic. HuaShi XuanFei Formula (HSXFF) was developed to treat patients with mild and general COVID-19 in Zhejiang Province, China. The present study seeks to explore its potentially active compounds and pharmacological mechanisms against COVID-19 based on network pharmacology, molecular docking, and molecular dynamics (MD) simulation. All components of HSXFF were harvested from the pharmacology database of the TCMSP system. COVID-19-related targets were retrieved from using OMIM and GeneCards databases. The herb-compound-targets network was constructed by Cytoscape. The target protein–protein interaction (PPI) network, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed to discover the potential key target genes and mechanism. The main active compounds of HSXFF were docked with 3C-like (3CL) protease hydrolase and angiotensin-converting enzyme 2 (ACE2). The MD simulation confirmed the binding stability of docking results. The herbs-targets network mainly contained 52 compounds and 70 corresponding targets, including key targets such as RELA, TNF, TP53, IL6, MAPK1, CXCL8, IL-1 β , and MAPK14. The GO and KEGG indicated that HSXFF may be mainly acting on the IL-17 signaling pathway, TNF signaling pathway, NF- κ B signaling pathway, etc. The molecular docking results indicated that isovitexin and procyanidin B1 showed the highest affinity with 3CL and ACE2, respectively, which were confirmed by MD simulation. These findings suggested HSXFF exerted therapeutic effects involving “multi-compounds and multi-targets.” It might be working through directly inhibiting the virus, improving immune function, and reducing the inflammatory in response to anti-COVID-19. In summary, the present study would provide a valuable direction for further research of HSXFF.

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Section: Discussionmentioning

confidence: 99%

Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis

Wang

Peng

et al. 2021

Mol Divers

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“…CHIKV [181] Vitexin Parainfluenza type 3 (Para 3) [182], Herpes simplex virus (HSV) type 1 and Hepatitis A virus (HAV)-H10 [183], SARS-CoV-2 [184][185][186][187], Influenza A viruses, A/Puerto Rico/8/1934 (PR8-H1N1) and A/Chicken/Taiwan/3937/2012 (3937-H6N1) [188] Isovitexin Influenza A viruses, A/Puerto Rico/8/1934 (PR8-H1N1) and A/Chicken/Taiwan/3937/2012 (3937-H6N1) [188], Hepatitis B virus (HBV) [189,190], Respiratory syncytial virus (RSV) and Influenza A1 virus (FM1) [191] Orientin SARS-CoV-2 [192], Parainfluenza type 3 virus [193], Herpes simplex virus 2 (HSV-2) [194] 4…”

Section: Luteolinmentioning

confidence: 99%

Nanotechnology Applications of Flavonoids for Viral Diseases

et al. 2021

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Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly recognized as prophylactic and therapeutic agents against emerging and old viral diseases. Around 10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based. Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and are effective against more viral diseases than currently used anti-virals. Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery of flavonoids, resulting in increased bioavailability.

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“…The extract derived from the seed coats of V. radiata (L.) R. Wilczek (VRE) inhibited influenza A virus in vitro through various mechanisms, including the blockade of viral entry, interference with assembly, and the repression of viral release (Lo et al. 2020 ). Considering the urgent need for effective antivirals to combat FIP, this study investigated VRE's inhibitory effect against FIPV and its underlying antiviral mechanism.…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of Vigna radiata extract against feline coronavirus in vitro

Chou,

Lin,

Chang

et al. 2024

Veterinary Quarterly

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Feline infectious peritonitis (FIP) is a fatal illness caused by a mutated feline coronavirus (FCoV). This disease is characterized by its complexity, resulting from systemic infection, antibody-dependent enhancement (ADE), and challenges in accessing effective therapeutics. Extract derived from Vigna radiata (L.) R. Wilczek (VRE) exhibits various pharmacological effects, including antiviral activity. This study aimed to investigate the antiviral potential of VRE against FCoV, addressing the urgent need to advance the treatment of FIP. We explored the anti-FCoV activity, antiviral mechanism, and combinational application of VRE by means of in vitro antiviral assays. Our findings reveal that VRE effectively inhibited the cytopathic effect induced by FCoV, reduced viral proliferation, and downregulated spike protein expression. Moreover, VRE blocked FCoV in the early and late infection stages and was effective under in vitro ADE infection. Notably, when combined with VRE, the polymerase inhibitor GS-441524 or protease inhibitor GC376 suppressed FCoV more effectively than monotherapy. In conclusion, this study characterizes the antiviral property of VRE against FCoV in vitro , and VRE possesses therapeutic potential for FCoV treatment.

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Vigna radiata (L.) R. Wilczek Extract Inhibits Influenza A Virus by Targeting Viral Attachment, Penetration, Assembly, and Release

Cited by 14 publications

References 34 publications

Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis

Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis

Nanotechnology Applications of Flavonoids for Viral Diseases

Antiviral activity of Vigna radiata extract against feline coronavirus in vitro

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