Villous and tubulovillous adenomas of the colon and rectum

Galandiuk, Susan; Fazio, Victor W.; Jagelman, David G.; Lavery, Ian C.; Weakley, Frank A.; Petras, Robert E.; Badhwar, Kavita; McGonagle, Beth A.; Eastin, Kelly; Sutton, T. Leonard

doi:10.1016/0002-9610(87)90199-1

Cited by 83 publications

(55 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Size, architecture, age, number of adenomas per patient, their localization within the colon and rectum, and the grade of dysplasia are considered to be factors associated with the malignant potential of adenomas in the colon and rectum [4,7,32].…”

Section: Discussionmentioning

confidence: 99%

Transanal endoscopic microsurgery in large, sessile adenomas of the rectum

Said

Stippel

1995

Surg Endosc

View full text Add to dashboard Cite

The clinical and long-term results of 286 cases encountered from 1983 to 1993 in our Department of Surgery regarding the local excision of large, sessile rectal adenomas (> 2 cm2) by the endoscopic surgical method and the influence of this selected series of adenomas on age, sex, size, grade of dysplasia, and architecture are subjects of this study. Histologically proven rectal carcinomas as well as non-neoplastic polyps were excluded from this trial. Early postoperative complications amounted to 3.4%. The 1-year and 5-year recurrence rates +/- SE of adenomas were 1.2 +/- 0.7% and 7.0 +/- 1.9%, respectively. Remarkably, there was no significant relationship between the histological type of the adenoma and the grade of dysplasia nor between the size and grade of dysplasia. However, there was a significant relationship between the size and histological type of the adenoma (P < 0.01). With the endoscopic minimal-invasive system, we are able to achieve a superior rate of recurrence compared to any other local treatment as well as a more favorable operative result compared to extensive surgical procedures.

show abstract

Section: Discussionmentioning

confidence: 99%

Transanal endoscopic microsurgery in large, sessile adenomas of the rectum

Said

Stippel

1995

Surg Endosc

View full text Add to dashboard Cite

show abstract

“…The Wnt target genes EphB2 and EphB3, expressed in the intestinal crypt, together with their ephrin B1 ligand, expressed on the villus epithelium, elicit cell repulsive mechanisms resulting in ingression of hyperproliferative APC ϩ/min crypt cells, yielding the morphology typical of adenomatous polyps (25). Loss of this compartmentalization, such as evoked by loss of ephrin B1, can lead to villous adenomas (9,62). This relationship is consistent with the loss of ephrin B1 and the villous phenotype of polyps observed in Cdx-Min offspring.…”

Section: Cdx1 and Cdx2 Act As Tumor Suppressors-aberrantmentioning

confidence: 99%

Cdx1 and Cdx2 Function as Tumor Suppressors

Hryniuk

Grainger

Savory

et al. 2014

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…The most common indication for a dorsal approach, however, is villous tumors that are located in the mid-rectum. The recurrence rate of villous adenomas after local excision has been described to range between 0 and 10% depending on the in situ carcinoma component of the lesion [6][7][8][9], and a diameter larger than 4 cm [10,11]. In our study, 3 recurrences (10%) were seen, including 1 invasive carcinoma.…”

Section: Discussionmentioning

confidence: 63%

The Place of the Posterior Surgical Approach for Lesions of the Rectum

et al. 2005

View full text Add to dashboard Cite

Background: Although there are many advantages of a posterior approach to rectal disease, these procedures are not widely accepted because many surgeons fear the postoperative complications. Methods: The medical records were reviewed of 57 patients who underwent a posterior approach to the rectum between January 1980 and December 2002. Results: Twenty-eight men and 29 women with a mean age of 70.5 (range 47–83) years underwent either a posterior transsacral (n = 52) or a transsphincteric (n = 5) procedure. Indications for surgery were benign lesions (n = 33), e.g. villous adenoma, rectal prolapse and endometriosis as well as invasive adenocarcinoma (n = 24). All patients with an invasive adenocarcinoma were classified as ASA grade III or IV. Postoperative morbidity occurred in 12 patients (21%), consisting of temporary incontinence, anastomotic leakage, wound infection, and hemorrhage. There was no mortality. During a mean follow-up of 29 (range 2–86) months, 3 patients with a villous adenoma and 2 patients who were treated for a malignant lesion had a locally recurrent lesion. Conclusion: We believe that a posterior approach to the rectum should be considered for various benign and selected malignant diseases, especially in case of elderly patients or patients with a compromised general condition, and has to be a part of the surgeon’s armamentarium.

show abstract

Villous and tubulovillous adenomas of the colon and rectum

Cited by 83 publications

References 14 publications

Transanal endoscopic microsurgery in large, sessile adenomas of the rectum

Transanal endoscopic microsurgery in large, sessile adenomas of the rectum

Cdx1 and Cdx2 Function as Tumor Suppressors

The Place of the Posterior Surgical Approach for Lesions of the Rectum

Contact Info

Product

Resources

About