Villous tumors of the large bowel

McCabe, John C.; McSherry, Charles K.; Sussman, Edward B.; Gray, George F.

doi:10.1016/s0002-9610(73)80121-7

Cited by 39 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Villous tumor shows a wide spectrum of benign, borderline, and malignant lesions. It is a relatively rare tumor of the colon and rectum and most often occurs within the rectum or sigmoid colon 2 , 6 , 14 , 15 . Its incidence is reported to comprise 1.4–7.4% of total colorectal tumors 16 –17 .…”

Section: Discussionmentioning

confidence: 99%

Villous tumor of the colon and rectum with special reference to roles of p53 and bcl‐2 in adenoma–carcinoma sequence

Yao

Kajiwara

Kouzuki

et al. 1999

Pathology International

View full text Add to dashboard Cite

Villous tumors are rare and their histological diagnosis from biopsy specimens is often difficult. To ascertain its tumor progression, including the genetic events, would be useful for clinical treatment. Clinicopathological features and the expression of p53 and bcl-2 proteins were investigated in 50 villous tumors from 49 patients. The patients' ages ranged widely from 32 to 84 years (average, 61 years). Females were more frequently affected than males (male:female ratio, 20:29). Thirty-six (72%) of the villous tumors were present within the sigmoid colon and rectum. Histologically, 17 (34%) of these contained carcinomas in villous adenomas (CIVA), while 24 (73%) of 33 villous adenomas (VA) contained high-grade dysplasia. Most of the CIVA revealed well-differentiated adenocarcinoma, often with focal or diffuse mucin pools. Three lesions of invasive carcinomas were composed of extremely well-differentiated components. The average size of the CIVA (79 mm) was significantly larger than that of the VA (51 mm). Overexpression of p53 protein was recognized in 12% of VA, in 24% of mucosal components of CIVA and in 18% of invasive components of CIVA. Overexpression of bcl-2 was recognized in 57% of VA, 33% of mucosal components of CIVA, and 7% of invasive components of CIVA. Several characteristic features were recognized in villous tumors, which comprised: (i) a high frequency of coexistence of carcinoma; (ii) multiple foci of carcinomas arising in adenomatous tumors; (iii) a lower histological grade of carcinomas, often with mucin pools; (iv) the existence of extremely well-differentiated adenocarcinomas; and (v) less frequent expression of p53 protein in the carcinomatous components. According to these findings, the pathway of tumor progression in the villous tumors is possibly different from that of sporadic colorectal carcinomas. Because of the peculiarity of villous tumors, careful clinical management is required.

show abstract

Section: Discussionmentioning

confidence: 99%

Villous tumor of the colon and rectum with special reference to roles of p53 and bcl‐2 in adenoma–carcinoma sequence

Yao

Kajiwara

Kouzuki

et al. 1999

Pathology International

View full text Add to dashboard Cite

show abstract

“…Villous colorectal neoplasms are rare and most often occur within the rectum or sigmoid colon 3–6 . They have been reported to comprise 1.4–7.4% of all colorectal tumours 7,8 …”

Section: Introductionmentioning

confidence: 99%

“…The high incidence of malignant transformation in villous tumours has been well documented. The incidence of coexistence of invasive carcinoma has been reported to be 15–28% 3–6 . Villous tumours show a wide spectrum of benign, ‘borderline’ and malignant lesions.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic alteration in malignant transformation of colonic villous tumours: with special reference to a comparison with tubular tumours

Takata

Yao

et al. 2003

Histopathology

View full text Add to dashboard Cite

There were significant differences in the phenotypic expression of adenoma and adenocarcinoma between villous and tubular tumours, respectively. Villous tumours have a pathway of malignant transformation different from that of tubular tumours. Because of biological differences, colorectal villous tumours should be distinguished from tubular neoplasia. The analysis of the phenotype of colorectal neoplasms is useful for the evaluation of tumour progression.

show abstract

“…Villöse Adenome zeigen dabei mit bis zu ca. 50% das höchste Entartungsrisiko [13]. Sie sind zu 90% im distalen Kolon (Rektum und Sigma) lokalisiert.…”

Section: Therapie Und Verlaufunclassified

Das sezernierende villöse Adenom als seltene Ursache einer akuten Niereninsuffizienz

Emrich¹,

Niemeyer²

2002

Medizinische Klinik

View full text Add to dashboard Cite

show abstract

Villous tumors of the large bowel

Cited by 39 publications

References 7 publications

Villous tumor of the colon and rectum with special reference to roles of p53 and bcl‐2 in adenoma–carcinoma sequence

Villous tumor of the colon and rectum with special reference to roles of p53 and bcl‐2 in adenoma–carcinoma sequence

Phenotypic alteration in malignant transformation of colonic villous tumours: with special reference to a comparison with tubular tumours

Das sezernierende villöse Adenom als seltene Ursache einer akuten Niereninsuffizienz

Contact Info

Product

Resources

About