Vincristine-Cyclophosphamide Combination Therapy Positively Affects T-Cell Subset Distribution in Systemic Lupus Erythematosus Patients

Ding, Lijuan; Wang, Meng; Yang, Jian; Yan, Chenglan; Xie, Jinchen; Luo, Jiaohua; Li, Xiaofeng; Fu, Zili

doi:10.12659/msm.893271

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Moreover, while cutaneous lupus responds to hydroxychloroquine, a satisfactory outcome with dapsone treatment has only sporadically been reported [4,5]. In the described case, dapsone treatment showed efficacy on skin lesions and the treatment was followed also by the complete remission of the other manifestations of the disease, without the employment of other immunosuppressive drugs [16]. …”

Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus and Bullous Pemphigoid with Dramatic Response to Dapsone

et al. 2017

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Patient: Female, 11Final Diagnosis: Bullous pemphigoid in systemic lupus erythematosusSymptoms: Bullous lupus • photosensitive rash • synovitisMedication:—Clinical Procedure: Pharmacological treatmentSpecialty: RheumatologyObjective:Unusual clinical courseBackground:Bullous pemphigoid is an autoimmune blistering disease, with relapses, isolated or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Joint manifestations rapidly respond to small or moderate doses of corticosteroids, whereas skin manifestations usually respond to antimalarial drugs.Case Report:We describe the clinical case of an 11-year-old girl with SLE. She showed bullous skin lesions with arthralgia, mild proteinuria, resolved after steroid treatment. At the tapering of her prednisone dose, the patient had new skin lesions requiring an increased dose of prednisone. She started dapsone at the dosage of 1 mg/kg/day, maintaining low dose prednisone; this treatment was successfully followed by the dramatic disappearance of skin lesions and limb pain.Conclusions:Bullous skin lesions can represent the first clinical presentation of pediatric SLE and could influence the treatment and the outcome of these patients.This case showed an atypical course as both skin manifestations and arthritis promptly and persistently resolved with dapsone without the use of high-dose glucocorticoids.Only a few cases of patients with SLE associated with bullous pemphigoid have been reported in the literature, and very few in the pediatric population.

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Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus and Bullous Pemphigoid with Dramatic Response to Dapsone

et al. 2017

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“…T cell can be divided into different subsets based on different surface antigens and antibody marked on the T lymphocytes. The level of CD3 + T cell reflects the total level of T lymphocyte, while CD4 + and CD8 + are major functional subsets of T cell [ 39 , 40 ]. CD4 + T cell represents helper T cell that helps lymphocytes differentiate and produce antibodies.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide

et al. 2018

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Lonicera japonica is a typical Chinese herbal medicine. We previously reported a method to isolate polysaccharides from Lonicera japonica (LJP). In this study, we first performed a qualitative analysis of LJP using the Fourier Transform Infrared Spectrometer (FT-IR) and explored the monosaccharide composition of LJP using the pre-column derivatization high performance liquid chromatography (HPLC) method. We then investigated the immunomodulatory function of LJP in cyclophosphamide (CTX)-induced immunosuppressed mouse models. The results showed that LJP had the characteristic absorption of typical polysaccharides consisting of 6 types of monosaccharides. In addition, LJP can increase significantly the organ index, splenic lymphocyte proliferation, macrophage phagocytosis, and natural killer (NK) cell activity in CTX-treated mice. LJP could also restore the levels of serum cytokines interleukin (IL-2), tumor necrosis factor (TNF-α) and Interferon-γ (IFN-γ) in the CTX-treated mice. Finally, the results on measuring the T-lymphocytes subsets of spleen also confirmed LJP-induced immunomodulatory activity in immunosuppressed mice from another perspective. Therefore, LJP could be used as a potential immunomodulatory agent.

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Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?

Alegria

Gazeau

Hillion

et al. 2017

Clinic Rev Allerg Immunol

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Considering the implications of B, T, and natural killer (NK) cells in the pathophysiology of systemic autoimmune diseases, the assessment of their distribution in the blood could be helpful for physicians in the complex process of determining a precise diagnosis. In primary Sjögren's syndrome, transitional and active naive B cells are increased and memory B cells are decreased compared to healthy controls and other systemic diseases. However, their utility to improve the accuracy of classification criteria has not been proven. In early untreated rheumatoid arthritis, proportions of regulatory T cells are constantly reduced, but other patterns are difficult to determine given the heterogeneity of published studies. In systemic lupus erythematosus, the lack of studies using large cohorts of patients and the diversity of the possible pathological mechanisms involved are also important impediments. Nevertheless, transitional B cell and plasma cell proportions are increased in most of the studies, the CD4/CD8 ratio is decreased, and the number of NK cells is reduced. Despite the low number of studies, anomalies of lymphocyte subset distribution was also described in ANCA-associated vasculitis, systemic scleroderma, and myositis. For now, flow cytometric analysis of lymphocyte subsets has focused mainly on specific subpopulations and is more useful for basic and translational research than for diagnostics in clinical practice. However, new modern methods such as mass cytometry and bioinformatics analyses may offer the possibility to simultaneously account for the relative proportions of multiple lymphocyte subsets and define a global profile in homogeneous groups of patients. The years to come will certainly incorporate such global lymphocyte profiling in reclassification of systemic autoimmune diseases.

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Vincristine-Cyclophosphamide Combination Therapy Positively Affects T-Cell Subset Distribution in Systemic Lupus Erythematosus Patients

Cited by 4 publications

References 23 publications

Systemic Lupus Erythematosus and Bullous Pemphigoid with Dramatic Response to Dapsone

Systemic Lupus Erythematosus and Bullous Pemphigoid with Dramatic Response to Dapsone

Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide

Could Lymphocyte Profiling be Useful to Diagnose Systemic Autoimmune Diseases?

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