Vincristine Induced Isolated Bilateral Ptosis in a Child with Wilms’ Tumour: Case Report with Review of Literature

Vaibhav, P; ey,; Gangopadhyay, A. N.; Sharma, Seema; Kumar, V.R. Ravi

doi:10.4172/2167-7700.1000112

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Laboratory testing, magnetic resonance imaging of the brain, and orbital ultrasonogram were normal. Most of the neuropathic symptoms of vincristine toxicity are reversible within months or years after adjusting the dosage or achieving the elimination of vincristine, although some are permanent [16]. In our patient, ptosis improved markedly after 20 days and completely resolved after four weeks.…”

Section: Discussionmentioning

confidence: 54%

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Unilateral Ptosis in a Child with Wilm’s Tumor Induced by Vincristine

Ouali¹,

Lahrache²,

Haddar³

et al. 2022

JCT

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Vincristine is a chemotherapy drug belonging to the group of Vinca alkaloids which also includes vinblastine and vindesine. It is used in hematological malignancies and solid tumors. The Vinca alkaloids are neurotoxic, usually causing peripheral neuropathy, and rarely cranial neuropathies. We report a case of a 33-month-old male child diagnosed with Wilms' tumor, who had an isolated unilateral right ptosis following vincristine, with a good improvement after stopping it.

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Section: Discussionmentioning

confidence: 54%

“…All cranial nerves may be affected, trigeminal and vagus nerves are frequently implicated [8]. Among ocular findings, ptosis and ophthalmoplegia may serve the clue [9]. Bilateral ptosis is the most common feature of vincristine-induced cranial neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Unilateral Ptosis in a Child with Wilm’s Tumor Induced by Vincristine

Ouali¹,

Lahrache²,

Haddar³

et al. 2022

JCT

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“…A study by Ozgur et al 2 also reported a case of VCR-induced ptosis with complete recovery after treatment with pyridoxine (150 mg/ m 2 ) alone. The study by Pandey et al 12 also reported full recovery of VCR-induced ptosis after three weeks of treatment with pyridostigmine (3 mg/kg oral twice daily) and pyridoxine (150 mg/m 2 oral twice daily). We used the same treatment regimen in our patient with pyridostigmine (3 mg/kg oral twice daily) and pyridoxine (150 mg/m 2 oral twice daily), which was very well tolerated with no documented side effects.…”

Section: Discussionmentioning

confidence: 87%

Vincristine-induced ptosis in a leukemia patient treated with pyridoxine and pyridostigmine

Johnson

Philip

et al. 2023

J Oncol Pharm Pract

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Introduction Blepharoptosis, commonly referred to as ptosis or eyelid sagging, is a condition where the upper eyelid droops over the eye. It can be congenital or acquired and is caused by the weakening of the eyelid muscles. Case report We present a case of a 3-year-old boy with T-cell acute lymphoblastic leukemia who developed bilateral ptosis while on treatment with Berlin–Frankfurt Munster-98 protocol. Management & outcome The patient was diagnosed with bilateral ptosis due to vincristine, the primary agent in the induction phase of the protocol. The addition of the neuroregenerative agents and supportive measures led to marked improvement, followed by complete resolution within 3 weeks. Discussion Vincristine is an anticancer agent with known neurotoxicity, which has a significant role in treating hematological malignancies and sarcoma. In many studies, the addition of neuroregenerative agents such as pyridoxine and pyridostigmine has been noted to hasten recovery without any documented side effects. Similar findings were also drawn from our research due to India's higher incidence of vincristine-induced neurotoxicity. It is essential to promptly diagnose and manage symptoms at the earliest to prevent the risk of permanent nerve damage and inferior quality of life for the patient.

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“…Similiar to Hatzipantelis, et al, our patient had bilateral ptosis post the vincristine treatment and showed significant improvement after neurobion intake which consists of pyridoxine and thiamine. The other cases were treated with a combination of pyridoxine and pyridostigmine [ 5 - 6 ]. The combinations are safe and effective treatment options in vincristine-induced ptosis and they speed up the recovery.…”

Section: Discussionmentioning

confidence: 99%

Combination of Pyridoxine and Thiamine Treatment in Bilateral Induced Ptosis in a Child - Case Report and Review of Literature

Chai¹,

Norsarwany²,

Shatriah³

2017

Cureus

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Ptosis is a rare side effect of vincristine chemotherapy in patients treated for cancer. We report a case of a child with common B-cell acute lymphoblastic leukemia who developed bilateral moderate ptosis following the chemotherapy protocol of the United Kingdom Acute Lymphoblastic Leukemia (ALL) regimen A. The patient showed dramatic clinical improvement after a combination of oral pyridoxine and thiamine treatment. We provide a literature review of this uncommon presentation.

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Vincristine Induced Isolated Bilateral Ptosis in a Child with Wilms’ Tumour: Case Report with Review of Literature

Cited by 3 publications

References 9 publications

Unilateral Ptosis in a Child with Wilm’s Tumor Induced by Vincristine

Unilateral Ptosis in a Child with Wilm’s Tumor Induced by Vincristine

Vincristine-induced ptosis in a leukemia patient treated with pyridoxine and pyridostigmine

Combination of Pyridoxine and Thiamine Treatment in Bilateral Induced Ptosis in a Child - Case Report and Review of Literature

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