Vincristine-induced polyneuropathy in a child with stage I Wilms’ tumour presenting with unilateral abducens nerve palsy

Panjawatanan, Panadeekarn; Charoenkwan, Pimlak; Katanyuwong, Kamornwan; Choeyprasert, Worawut

doi:10.1136/bcr-2014-204524

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Снижение содержания в плазме крови всех наиболее распространенных форм витамина В 6 наблюдается у пациентов с СД, считается, что наряду с дефицитом и других витаминов группы В, активацией процессов воспаления и эндотелиальной дисфункции это является важным фактором риска развития поражения различных органов и систем организма, в том числе периферической нервной системы [29]. Уcтановлена роль нарушений метаболизма пиридоксина при целом ряде токсических (лекарственных) и других полинейропатий [30,31]. Крайне редким состоянием является пиридоксининдуцированное поражение нервной системы, причины развития которого не вполне понятны [32].…”

Section: îáùèå ïðèíöèïû ëå÷åíèÿ áîëåâûõ ñèíäðîìîâunclassified

Choosing of therapy for a patient with dorsalgia

Камчатнов

Абусуева²,

Khanmurzaeva³

et al. 2020

Terapevticheskii arkhiv

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Dorsalgia is one of the most common skeletal muscle syndromes. Dorsalgia often develops in patients of older age groups with polymorbidity that requires the appointment of a large number of medications. In these conditions, the choice of effective and safe therapy is a difficult problem. Discusses management of a patient suffering dorsalgia with comorbidities, the risks of complications of therapy, possible safety treatment, in particular, through the use of combination therapy.

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Section: îáùèå ïðèíöèïû ëå÷åíèÿ áîëåâûõ ñèíäðîìîâunclassified

Choosing of therapy for a patient with dorsalgia

Камчатнов

Абусуева²,

Khanmurzaeva³

et al. 2020

Terapevticheskii arkhiv

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Vincristine

2014

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S VincristineAbducens nerve palsy and peripheral neuropathy in a child: case report A 4-year-old boy developed abducens nerve palsy and peripheral neuropathy following treatment with vincristine for Wilms' tumour.The boy presented with right esotropia. After diagnosis of Wilms' tumour of the right kidney, he was administered adjuvant vincristine 1.5 -2 mg/m 2 /dose [route and frequency not stated] following right nephrectomy. After his eleventh dose of vincristine, 9mg cumulative dose, right esotropia was observed, during the 16th week of chemotherapy. He was glucose-6-phosphate dehydrogenase deficient. Physical examination showed a right, isolated, lateral rectus palsy; deep tendon reflex grading was unreliable. Tests showed the following values: WBC count 5100/mm 3 , platelet count 242 000/mm 3 and haemoglobin 11 g/dL. CSF examination revealed an acellular specimen. Nerve conduction velocity study showed mainly motor polyneuropathy consistent with axonal loss affecting the arms. Vincristine-induced neuropathy of the abducens nerve was suspected.Vincristine was withdrawn, and pyridoxine was initiated. The boy's esotropia regressed; after 8 months, mild residual esotropia was noted without any clinical symptoms of peripheral neuropathy or motor weakness.Author comment: "With the history of exposure to vincristine and the abnormal NCV, the cause of the abducens palsy in our patient was most likely to be vincristine-induced cranial neuropathy. The abnormal NCV study also depicted subclinical peripheral neuropathy." Panjawatanan P, et al. Vincristine-induced polyneuropathy in a child with stage I Wilms' tumour presenting with unilateral abducens nerve palsy. BMJ Case Reports : No.

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Vincristine-induced polyneuropathy in a child with stage I Wilms’ tumour presenting with unilateral abducens nerve palsy

Cited by 2 publications

References 16 publications

Choosing of therapy for a patient with dorsalgia

Choosing of therapy for a patient with dorsalgia

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