2017
DOI: 10.1002/pbc.26728
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VIncristine, irinotecan, and temozolomide in children and adolescents with relapsed rhabdomyosarcoma

Abstract: Background: The combination of vincristine, irinotecan, and temozolomide (VIT) is often used to treat children and adolescents with relapsed rhabdomyosarcoma (RMS); however, the outcome of these patients has not been previously described. Procedures:We sought to determine the response rate (RR) and progression-free survival (PFS) for patients with relapsed RMS treated with VIT by retrospective review of patients treated at five tertiary care hospitals. Prior treatment with irinotecan was permitted.

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Cited by 34 publications
(36 citation statements)
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“…Vincristine, a major compound of Catharanthus roseus , has been demonstrated to potently attenuate a series of malignancies, including colon cancer, metastatic breast cancer, and rhabdomyosarcoma [ 63 , 64 , 65 ]. The most therapeutic mechanism of inducing tumor death by vincristine is to break the polymerization of mitotic spindle microtubules and continuous arrests cell division during metaphase.…”
Section: Molecular Mechanisms Involved In Tcm-induced Oxidative Hementioning
confidence: 99%
“…Vincristine, a major compound of Catharanthus roseus , has been demonstrated to potently attenuate a series of malignancies, including colon cancer, metastatic breast cancer, and rhabdomyosarcoma [ 63 , 64 , 65 ]. The most therapeutic mechanism of inducing tumor death by vincristine is to break the polymerization of mitotic spindle microtubules and continuous arrests cell division during metaphase.…”
Section: Molecular Mechanisms Involved In Tcm-induced Oxidative Hementioning
confidence: 99%
“…For relapsed disease (RD) of RMS in children there is still no clear recommendation concerning the use of salvage CHT. Recently, various second‐line regimes were published . Radiotherapy (RT) is also viewed with caution, and little is known about long‐term sequelae and second malignancies after CHT and RT in the early childhood.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, various second-line regimes were published. [8][9][10] Radiotherapy (RT) is also viewed with caution, and little is known about long-term sequelae and second malignancies after CHT and RT in the early childhood.…”
Section: Introductionmentioning
confidence: 99%
“…Survival related events include disease progression, disease relapse, second tumor and death of any cause [9][10][11]. Treatment related second tumor and death of other cause (tumor progression or relapse unrelated cause) are rare, while disease progression and relapse comprise almost all events [9,17,18]. In most studies patients with disease progression and relapse were analyzed as a combined single group, using EFS rate to evaluate prognosis.…”
Section: Discussionmentioning
confidence: 99%