Vindoline—A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes

Oguntibeju, Oluwafemi Omoniyi; Aboua, Yapo Guillaume; Goboza, Mediline

doi:10.3390/biomedicines7030059

Cited by 20 publications

(15 citation statements)

References 44 publications

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“…Vindoline is suggested to be one of a major alkaloid compound in C. roseus and has been demonstrated to possess antidiabetic activities 27 . More importantly, vindoline is condensed with catharanthine to generate the anticancer drugs vinblastine and vincristine.…”

Section: Discussionmentioning

confidence: 99%

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

et al. 2021

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Vindoline is a plant derived monoterpene indole alkaloid (MIA) with potential therapeutic applications and more importantly serves as the precursor to vinblastine and vincristine. To obtain a yeast strain for high yield production of vindoline from tabersonine, multiple metabolic engineering strategies were employed via the CRISPR/Cas9 mediated multiplex genome integration technology in the present study. Through increasing and tuning the copy numbers of the pathway genes, pairing cytochrome P450 enzymes (CYPs) with appropriate cytochrome P450 reductases (CPRs), engineering the microenvironment for functional expression of CYPs, enhancing cofactor supply, and optimizing fermentation conditions, the production of vindoline was increased to a final titer as high as ∼16.5 mg/L, which is more than 3,800,000-fold higher than the parent strain and the highest tabersonine to vindoline conversion yield ever reported. This work represents a key step of the engineering efforts to establish de novo biosynthetic pathways for vindoline, vinblastine, and vincristine.

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Section: Discussionmentioning

confidence: 99%

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

et al. 2021

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“…The administration of vindoline significantly improved oxygen radical absorbance capacity (ORAC), an assay measuring the ability of antioxidants in a particular sample to scavenge radicals, and improved SOD activity in the livers of rats exposed to 10% fructose with STZ employed as a DM2 model [94]. Using the above rat DM2 model, treatment with vindoline improved the ferric-reducing antioxidant power (FRAP) in cardiac tissue significantly improved the ORAC and SOD activity and significantly reduced MDA levels in the kidneys [93]. Oxymatrine, a major quinolizidine alkaloid in Sophora flavescens, exhibits several pharmacological effects, such as anti-inflammatory, anti-oxidative, and neuroprotective activity.…”

Section: Alkaloidsmentioning

confidence: 99%

“…↑ FRAP in the cardiac tissue, ↑ ORAC, ↓ MDA levels in the kidneys.↑ SOD activity in the liver. ↑ SOD activity [93,94]. Oxymatrine HFD/STZ-induced DM2 rats ↓ blood glucose and ↓ MDA levels.…”

mentioning

confidence: 96%

The Use of Natural Compounds as a Strategy to Counteract Oxidative Stress in Animal Models of Diabetes Mellitus

Salazar–García

Corona

2021

IJMS

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Diabetes mellitus (DM) is a chronic metabolic disease characterised by insulin deficiency, resulting in hyperglycaemia, a characteristic symptom of type 2 diabetes mellitus (DM2). DM substantially affects numerous metabolic pathways, resulting in β-cell dysfunction, insulin resistance, abnormal blood glucose levels, impaired lipid metabolism, inflammatory processes, and excessive oxidative stress. Oxidative stress can affect the body’s normal physiological function and cause numerous cellular and molecular changes, such as mitochondrial dysfunction. Animal models are useful for exploring the cellular and molecular mechanisms of DM and improving novel therapeutics for their safe use in human beings. Due to their health benefits, there is significant interest in a wide range of natural compounds that can act as naturally occurring anti-diabetic compounds. Due to rodent models’ relatively similar physiology to humans and ease of handling and housing, they are widely used as pre-clinical models for studying several metabolic disorders. In this review, we analyse the currently available rodent animal models of DM and their advantages and disadvantages and highlight the potential anti-oxidative effects of natural compounds and their mechanisms of action.

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“…Traditionally, a decoction made from leaf extracts is used to treat rheumatism, venereal diseases, skin infections, high blood pressure, diabetes mellitus, and many others [ 26 , 90 ]. In Madagascar, the extract from the plant is used as purgative, vomitive, and for relieving toothache [ 118 , 121 ].…”

Section: Biological Application Of Mnps Synthesized From Some Selected South African Medicinal Plantsmentioning

confidence: 99%

Green Synthesis of Metallic Nanoparticles Using Some Selected Medicinal Plants from Southern Africa and Their Biological Applications

Aboyewa

Sibuyi

Meyer

et al. 2021

Plants

106

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The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their functions, which are attributed to their physicochemical properties, have gained prominence in various technological fields. Although MNPs can be produced via rigorous physical and chemical techniques, in recent years, a biological approach utilizing natural materials has been developed. With the increasing enthusiasm for safe and efficient nanomaterials, the biological method incorporating microorganisms and plants is preferred over physical and chemical methods of nanoparticle synthesis. Of these bio-entities, plants have received great attention owing to their capability to reduce and stabilize MNPs in a single one-pot protocol. South Africa is home to ~10% of the world’s plant species, making it a major contributor to the world’s ecological scenery. Despite the documented contribution of South African plants, particularly in herbal medicine, very few of these plants have been explored for the synthesis of the noble MNPs. This paper provides a review of some important South African medicinal plants that have been utilized for the synthesis of MNPs. The enhanced biological properties of the biogenic MNPs attest to their relevance in medicine. In this endeavour, more of the African plant biodiversity must be explored for the synthesis of MNPs and be validated for their potential to be translated into future nanomedicine.

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Vindoline—A Natural Product from Catharanthus Roseus Reduces Hyperlipidemia and Renal Pathophysiology in Experimental Type 2 Diabetes

Cited by 20 publications

References 44 publications

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

Efficient production of vindoline from tabersonine by metabolically engineered Saccharomyces cerevisiae

The Use of Natural Compounds as a Strategy to Counteract Oxidative Stress in Animal Models of Diabetes Mellitus

Green Synthesis of Metallic Nanoparticles Using Some Selected Medicinal Plants from Southern Africa and Their Biological Applications

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